PMID- 8618009
OWN - NLM
STAT- MEDLINE
DCOM- 19960613
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 106
IP  - 4
DP  - 1996 Apr
TI  - Familial juvenile onset psoriasis is associated with the human leukocyte antigen 
      (HLA) class I side of the extended haplotype 
      Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0303: a population- and family-based study.
PG  - 711-4
AB  - To further evaluate the nature of the HLA association with psoriasis, HLA 
      haplotypes of 60 patients with type 1 (early onset, positive family history) and 
      30 patients with type II (late onset, no family history) psoriasis were 
      investigated by polymerase chain reaction sequence-specific oligonucleotide 
      hybridization (HLA class II) and serology (HLA class I). Ethnically matched blood 
      donors (146) served as controls. In type I, but not type II psoriasis, the 
      Caucasian HLA extended haplotype (EH) Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0303 named 
      according to the B allele EH-57.1 was highly significantly overrepresented (p 
      cor= 0.00021). This particular EH was present in 35% of type I psoriatics but 
      only 2% of controls. EH-57.1+ individuals therefore carry a 26 times higher risk 
      of developing type I psoriasis than individuals who are EH-57.1-negative Further 
      analysis of individual HLA alleles revealed that within EH-57.1, HLA class I 
      antigens (Cw6-B57) were associated to a much higher extent with type I psoriasis 
      than the HLA class II alleles (DRB1*0701-DQA1*0201-DQB1* 0303). Pedigree analysis 
      of three multiply affected families over three generations revealed a 
      cosegregation of disease with EH-57.1. These results strongly suggest that a gene 
      for familial psoriasis is associated with the class I side of the extended 
      haplotype Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0303.
FAU - Schmitt-Egenolf, M
AU  - Schmitt-Egenolf M
AD  - Department of Dermatology, School of Medicine (Charite), Humboldt University, 
      Berlin, Germany.
FAU - Eiermann, T H
AU  - Eiermann TH
FAU - Boehncke, W H
AU  - Boehncke WH
FAU - Stander, M
AU  - Stander M
FAU - Sterry, W
AU  - Sterry W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*06 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Base Sequence
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - Molecular Sequence Data
MH  - Psoriasis/genetics/*immunology
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - S0022-202X(15)42518-7 [pii]
AID - 10.1111/1523-1747.ep12345600 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1996 Apr;106(4):711-4. doi: 10.1111/1523-1747.ep12345600.