PMID- 8618812
OWN - NLM
STAT- MEDLINE
DCOM- 19960610
LR  - 20170306
VI  - 94
IP  - 6
DP  - 1995 Dec
TI  - [Humoral immune response to tissue injury, characterized by a rise in serum 
      immunoglobulin E].
PG  - 495-505
AB  - We have observed that acute myocardial infarction is associated with the 
      immunological response characterized a transient rise of serum immunoglobulin E 
      (IgE). We wondered whether this reaction was specific for myocardial infarction 
      or whether it reflected a more generalized phenomenon, perhaps triggered by 
      tissue injury. We, therefore, made a large prospective study on patients 
      undergoing various surgical procedures. These were the patients undergoing 
      coronary artery bypass graft, who did (n = 39) or did not (n = 42) develop 
      perioperative myocardial infarction, patients subjected to thoracic operations (n 
      = 33) patients having cholecystectomy (n = 17) or repair of the inguinal hernia 
      (n = 18) and 30 healthy volunteers forming the control group. Blood samples were 
      drawn before the operation and then after the operation at 8, 16, 24, 48, 72, 
      120, 168 and 216 hours. In all samples, concentrations of serum immunoglobulins E 
      were determined on blinded specimens by an automated microparticle enzyme 
      immunoassay while immunoglobulins G, A and M were determined using nephelometry. 
      In all groups studied, except the control group, serum IgE began to rise shortly 
      after the operations reached a peak by the fifth day, and then gradually 
      declined. This behaviour of IgE serum levels was in striking contrast to that of 
      the remaining serum immunoglobulins G, A and M which showed a rapid fall after 
      surgical interventions, followed by a gradual return to the initial values. The 
      stimulation of hypothalamus-adrenal axis and release of glucocorticosteroids, 
      interacting with de novo synthesized interleukin-6, could explain this newly 
      observed phenomenon of the immunoglobulin E response to the tissue injury. 
      Behaviour of serum IgE, as described by us, bears much resemblance to that of 
      acute phase proteins. In conclusion, we hypothesize that immunoglobulin E may act 
      in human organism as an acute phase protein.
FAU - Szczeklik, A
AU  - Szczeklik A
AD  - II Katedry Chorob Wewnetrznych Collegium Medicum Uniwersytetu Jagiellonskiego w 
      Krakowie.
FAU - Jawien, J
AU  - Jawien J
LA  - pol
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Humoralna odpowiedz immunologiczna na uraz tkanki, cechujaca sie wzrostem 
      stezenia immunoglobuliny E w surowicy krwi.
PL  - Poland
TA  - Pol Arch Med Wewn
JT  - Polskie Archiwum Medycyny Wewnetrznej
JID - 0401225
RN  - 0 (Acute-Phase Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Acute-Phase Proteins/immunology
MH  - Adult
MH  - Aged
MH  - Antibody Formation/*immunology
MH  - Coronary Artery Bypass/adverse effects
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/etiology/*immunology
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Surgical Procedures, Operative
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
PST - ppublish
SO  - Pol Arch Med Wewn. 1995 Dec;94(6):495-505.