PMID- 8621212
OWN - NLM
STAT- MEDLINE
DCOM- 19960614
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 27
IP  - 5
DP  - 1996 May
TI  - Effect of salt intake and inhibitor dose on arterial hypertension and renal 
      injury induced by chronic nitric oxide blockade.
PG  - 1165-72
AB  - Long-term nitric oxide blockade by N omega -nitro-L-arginine methyl ester 
      (L-NAME) leads to severe and progressive hypertension. The role of salt intake in 
      this model is unclear. To verify whether salt dependence in this model is related 
      to the extent of nitric oxide inhibition, we gave adult male Munich-Wistar rats a 
      low salt, standard salt, or high salt diet and oral L-NAME treatment at either 3 
      or 25 mg/kg per day. At 10 to 15 days of treatment, the slope of the 
      pressure-natriuresis line was decreased in rats receiving low-dose L-NAME 
      compared with untreated controls. In rats treated with the higher dose, the line 
      was shifted to the right but remained parallel to that obtained in untreated 
      controls. Renal vascular resistance was moderately increased in rats receiving 
      low-dose L-NAME, whereas high-dose L-NAME induced a marked vasoconstriction that 
      was aggravated by salt overload. Low-dose L-NAME treatment induced hypertension 
      only when associated with sodium overload. In rats receiving high-dose L-NAME, 
      hypertension was aggravated by sodium excess but was not ameliorated by sodium 
      restriction. Long-term (6 weeks) L-NAME treatment was associated with progressive 
      hypertension, which was aggravated by salt overload, and with the development of 
      albuminuria, focal glomerular collapse, glomerulosclerosis, and renal 
      interstitial expansion. These abnormalities were worsened by salt overload and 
      largely prevented by salt restriction. In the model of chronic nitric oxide 
      blockade, salt dependence is a function of the inhibitor dose, and renal injury 
      varies directly with the level of salt intake.
FAU - Yamada, S S
AU  - Yamada SS
AD  - Department of Clinical Medicine, University of Sao Paulo Brazil School of 
      Medicine, Brazil.
FAU - Sassaki, A L
AU  - Sassaki AL
FAU - Fujihara, C K
AU  - Fujihara CK
FAU - Malheiros, D M
AU  - Malheiros DM
FAU - De Nucci, G
AU  - De Nucci G
FAU - Zatz, R
AU  - Zatz R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 3.4.23.15 (Renin)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Albuminuria
MH  - Animals
MH  - Arginine/*analogs & derivatives/pharmacology
MH  - *Diet, Sodium-Restricted
MH  - Dose-Response Relationship, Drug
MH  - Hemodynamics
MH  - Hypertension/pathology/*physiopathology
MH  - Kidney/pathology
MH  - Kidney Diseases/*etiology/pathology
MH  - Male
MH  - NG-Nitroarginine Methyl Ester
MH  - Natriuresis
MH  - Nitric Oxide/*antagonists & inhibitors
MH  - Rats
MH  - Rats, Wistar
MH  - Renal Circulation
MH  - Renin/blood
MH  - Time Factors
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1161/01.hyp.27.5.1165 [doi]
PST - ppublish
SO  - Hypertension. 1996 May;27(5):1165-72. doi: 10.1161/01.hyp.27.5.1165.