PMID- 8621252
OWN - NLM
STAT- MEDLINE
DCOM- 19960618
LR  - 20160303
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 66
IP  - 3
DP  - 1996 May 3
TI  - Serum trypsinogen-2 and trypsin-2-alpha(1)-antitrypsin complex in malignant and 
      benign digestive-tract diseases. Preferential elevation in patients with 
      cholangiocarcinomas.
PG  - 326-31
AB  - Serum concentrations of trypsinogen-2 and trypsin-2-alpha(1)-antitrypsin 
      (trypsin-2-AAT) were determined in 145 patients with malignant and 61 with benign 
      digestive-tract diseases. The validity of these tests for detection of cancer was 
      compared with that of CA 19-9 and CEA. Elevated levels of trypsinogen-2 (>90 
      micrograms/l) and trypsin-2-AAT (>25 micrograms/l) were found in 46% and 42%, 
      respectively, of patients with malignant disease and the levels of trypsinogen-2 
      were significantly higher than in those with benign disease (p<0.005). High 
      trypsinogen-2 and trypsin-2-AAT concentrations were found most often in patients 
      with biliary and pancreatic cancer, but also in benign obstructive biliary 
      disease. Our results suggest that trypsinogen-2 and trypsin-2-AAT are new 
      potential markers for cholangiocarcinomas.
FAU - Hedstrom, J
AU  - Hedstrom J
AD  - Department of Clinical Chemistry, Helsinki University Central Hospital, Finland.
FAU - Haglund, C
AU  - Haglund C
FAU - Haapiainen, R
AU  - Haapiainen R
FAU - Stenman, U H
AU  - Stenman UH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Biomarkers)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (alpha 1-Antitrypsin)
RN  - 103964-84-7 (PRSS2 protein, human)
RN  - 9002-08-8 (Trypsinogen)
RN  - EC 3.2.1.- (Amylases)
RN  - EC 3.4.21.4 (Trypsin)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Amylases/blood
MH  - Bile Duct Neoplasms/*blood/enzymology
MH  - Bilirubin/blood
MH  - Biomarkers/blood
MH  - Biomarkers, Tumor/blood
MH  - Carcinoma, Hepatocellular/blood
MH  - Cholangiocarcinoma/*blood/enzymology
MH  - Digestive System Diseases/*blood/enzymology
MH  - Digestive System Neoplasms/*blood/enzymology
MH  - False Positive Reactions
MH  - Humans
MH  - Liver Neoplasms/blood
MH  - Pancreatic Neoplasms/blood
MH  - Trypsin/*analysis
MH  - Trypsinogen/*blood
MH  - alpha 1-Antitrypsin/*analysis
EDAT- 1996/05/03 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/05/03 00:00
PHST- 1996/05/03 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/05/03 00:00 [entrez]
AID - 10.1002/(SICI)1097-0215(19960503)66:3<326::AID-IJC10>3.0.CO;2-9 [pii]
AID - 10.1002/(SICI)1097-0215(19960503)66:3<326::AID-IJC10>3.0.CO;2-9 [doi]
PST - ppublish
SO  - Int J Cancer. 1996 May 3;66(3):326-31. doi: 
      10.1002/(SICI)1097-0215(19960503)66:3<326::AID-IJC10>3.0.CO;2-9.