PMID- 8624101
OWN - NLM
STAT- MEDLINE
DCOM- 19960614
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 777
DP  - 1996 Jan 17
TI  - beta-APP cognitive function versus beta-amyloid--induced cell death.
PG  - 293-6
AB  - The beta-amyloid precursor protein (beta-APP) has been hypothesized to play an 
      important role in the establishment of synaptic connections. Icv injections of 
      anti-beta APP antibodies into rat brains produced no appreciable effect on 
      subsequent learning of a passive avoidance task whereas memory assessed 1 day 
      later in a retention test was impaired in anti-beta-APP--but not 
      control-IgG-injected animals. This suggests a possible involvement of beta-APPs 
      in cognitive functions. In order to evaluate the properties of the proteolytic A 
      beta-fragment accumulating in Alzheimer's disease brains, four different neuronal 
      cell types were exposed to A beta 1-42 for 24 hours. All cells degenerated in 
      response to A beta, yet chromosomal condensation and internucleosomal DNA 
      fragmentation, typical for apoptosis, occurred in only three of the cell types 
      tested. These findings suggest that beta-APPs may play an important role in 
      cognitive processes and additionally, that their alternative proteolytic product 
      A beta may be differentially toxic to neuronal cell types, inducing cell death 
      either by necrosis or by apoptosis.
FAU - Gschwind, M
AU  - Gschwind M
AD  - Pharma Division, Preclinical CNS Research, F. Hoffmann-La Roche Ltd., Basel, 
      Switzerland.
FAU - Martin, J R
AU  - Martin JR
FAU - Moreau, J L
AU  - Moreau JL
FAU - Huber, G
AU  - Huber G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Neurotoxins)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Amyloid beta-Peptides/*pharmacology
MH  - Amyloid beta-Protein Precursor/*physiology
MH  - Animals
MH  - Cell Death
MH  - Cognition/*physiology
MH  - Cricetinae
MH  - Neurons/*drug effects/physiology
MH  - Neurotoxins/*pharmacology
MH  - Peptide Fragments/pharmacology
MH  - Rabbits
MH  - Rats
MH  - Tumor Cells, Cultured
EDAT- 1996/01/17 00:00
MHDA- 1996/01/17 00:01
CRDT- 1996/01/17 00:00
PHST- 1996/01/17 00:00 [pubmed]
PHST- 1996/01/17 00:01 [medline]
PHST- 1996/01/17 00:00 [entrez]
AID - 10.1111/j.1749-6632.1996.tb34435.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1996 Jan 17;777:293-6. doi: 10.1111/j.1749-6632.1996.tb34435.x.