PMID- 8624458
OWN - NLM
STAT- MEDLINE
DCOM- 19960626
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 20
IP  - 3-4
DP  - 1996 Jan
TI  - Clinical implication of the integration patterns of human T-cell lymphotropic 
      virus type I proviral DNA in adult T-cell leukemia/lymphoma.
PG  - 207-15
AB  - In this review, we discuss the possible relationship between the clinical 
      characteristics and the integration patterns of human T-cell lymphotropic virus 
      type I (HTLV-I) proviral DNA in patients with adult T-cell leukemia/ lymphoma 
      (ATL). Some ATL patients show unusual integration patterns such as multiple or 
      defective HTLV-I and have clinical characteristics unlike those of most ATL 
      patients who have the characteristic integration pattern of one complete 
      provirus. Multiple HTLV-I integrations can be detected as two or more bands using 
      the standard Southern blotting method when the tumor cellular DNA is digested 
      with an endonuclease that does not cleave within the provirus. This includes 
      cases of one tumor cell clone carrying two or more copies of the provirus, or 
      alternatively two or more cell clones, each carrying one copy of the provirus. 
      The former group of patients always manifest severe dyspnea and hypoxemia with 
      unusual organ infiltrations including the retina and muscle and an extremely 
      aggressive clinical course. On the other hand, the latter group of patients have 
      an indolent course with skin lesions or small T lymphocytes with cleaved or 
      lobulated nuclei. A solitary defective HTLV-I in some ATL patients can be 
      detected as one smaller band after digestion of cellular DNA with an endonuclease 
      that does not cleave within the provirus. These patients generally have a 
      favourable clinical course with small cleaved or bilobulated T lymphocytes 
      without lymphadenopathy or skin lesions. These findings suggest that there are 
      clinical implications for the integration patterns of HTLV-I and this may be one 
      of the explanations for the heterogeneous behaviour of the disease. Such studies 
      may provide information on the relationship between virus integration and the 
      clinical manifestations and also improve our understanding of the pathogenesis of 
      ATL.
FAU - Shimamoto, Y
AU  - Shimamoto Y
AD  - Department of Internal Medicine, Saga Medical School, Japan.
FAU - Kobayashi, M
AU  - Kobayashi M
FAU - Miyamoto, Y
AU  - Miyamoto Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adult
MH  - DNA, Neoplasm/genetics
MH  - Defective Viruses/genetics
MH  - Human T-lymphotropic virus 1/*genetics
MH  - Humans
MH  - Leukemia, T-Cell/*microbiology/pathology
MH  - Pleural Effusion
MH  - Proviruses/genetics
MH  - Virus Integration
RF  - 51
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.3109/10428199609051609 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 1996 Jan;20(3-4):207-15. doi: 10.3109/10428199609051609.