PMID- 8624731
OWN - NLM
STAT- MEDLINE
DCOM- 19960624
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 700
IP  - 1-2
DP  - 1995 Nov 27
TI  - Selective transport of blood-borne interleukin-1 alpha into the posterior 
      division of the septum of the mouse brain.
PG  - 83-8
AB  - Film autoradiography was used to demonstrate the transport and sites of 
      accumulation of blood-borne radioiodinated interleukin-1 alpha (II-1 alpha) and 
      other cytokines into the brain after intravenous administration. [125 I]Il-1 
      alpha, [125I]Il-1 beta, [125I]interleukin-1 receptor antagonist (II-1ra), and 
      [125I]tumor necrosis factor-alpha (TNF alpha) labeled the choroid plexus and the 
      capillary network 30 min after injection into the blood, suggesting that these 
      areas may serve as sites of blood-to-brain transport. [125I]Il-1alpha, but not 
      [125I]Il-1beta, [125I]Il-1ra, [125I]TNF alpha, or [125I]interleukin-2 (Il-2), was 
      also found localized to the caudal region of the septal nuclei. Only unlabeled 
      II-1 alpha was able to inhibit this accumulation. These findings provide further 
      evidence for the passage of select cytokines across the blood-brain barrier (BBB) 
      and are the first to identify a target site within the central nervous system 
      (CNS) for a transported cytokine.
FAU - Maness, L M
AU  - Maness LM
AD  - Department of Neuroscience, Tulane University School of Medicine, New Orleans, 
      LA, USA.
FAU - Banks, W A
AU  - Banks WA
FAU - Zadina, J E
AU  - Zadina JE
FAU - Kastin, A J
AU  - Kastin AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Blood-Brain Barrier/*physiology
MH  - Central Nervous System/*metabolism
MH  - Cytokines/*metabolism
MH  - Interleukin-1/blood/*pharmacokinetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Septal Nuclei/*metabolism
EDAT- 1995/11/27 00:00
MHDA- 1995/11/27 00:01
CRDT- 1995/11/27 00:00
PHST- 1995/11/27 00:00 [pubmed]
PHST- 1995/11/27 00:01 [medline]
PHST- 1995/11/27 00:00 [entrez]
AID - 0006-8993(95)00913-B [pii]
AID - 10.1016/0006-8993(95)00913-b [doi]
PST - ppublish
SO  - Brain Res. 1995 Nov 27;700(1-2):83-8. doi: 10.1016/0006-8993(95)00913-b.