PMID- 8625253 OWN - NLM STAT- MEDLINE DCOM- 19960621 LR - 20190816 IS - 0165-4608 (Print) IS - 0165-4608 (Linking) VI - 87 IP - 2 DP - 1996 Apr TI - More detailed characterization of some of the HL60 karyotypic features by fluorescence in situ hybridization. PG - 103-6 AB - We performed a focused chromosome analysis on the HL60 cell line by multicolor fluorescence in situ hybridization (FISH), using probes for the unequivocal identification of specific chromosome regions and subregions. The purpose of this karyotypic re-evaluation was to confirm and to characterize in more detail chromosome rearrangements already identified by means of classic cytogenetic approaches and recurrently detected from the initial establishment of the cell line. The observations reported may help reassess the potential of the HL60 cell line in understanding the molecular events underlying the non-random karyotype alterations associated with acute myeloid leukemias (AML). FAU - Volpi, E V AU - Volpi EV AD - Istituto di Genetica Molecolare del CNR, Alghero, Italy. FAU - Vatcheva, R AU - Vatcheva R FAU - Labella, T AU - Labella T FAU - Gan, S U AU - Gan SU LA - eng PT - Journal Article PL - United States TA - Cancer Genet Cytogenet JT - Cancer genetics and cytogenetics JID - 7909240 SB - IM MH - *Chromosome Aberrations MH - Chromosomes, Artificial, Yeast MH - *Chromosomes, Human, Pair 17 MH - HL-60 Cells MH - Humans MH - In Situ Hybridization, Fluorescence MH - Karyotyping MH - Leukemia, Myeloid, Acute/*genetics EDAT- 1996/04/01 00:00 MHDA- 1996/04/01 00:01 CRDT- 1996/04/01 00:00 PHST- 1996/04/01 00:00 [pubmed] PHST- 1996/04/01 00:01 [medline] PHST- 1996/04/01 00:00 [entrez] AID - 0165460895002146 [pii] AID - 10.1016/0165-4608(95)00214-6 [doi] PST - ppublish SO - Cancer Genet Cytogenet. 1996 Apr;87(2):103-6. doi: 10.1016/0165-4608(95)00214-6.