PMID- 8625264
OWN - NLM
STAT- MEDLINE
DCOM- 19960621
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 87
IP  - 2
DP  - 1996 Apr
TI  - Metastatic extraosseous Ewing tumor. Association of the additional translocation 
      der(16)t(1;16) with the variant EWS/ERG rearrangement in a case of 
      cytogenetically inconspicuous chromosome 22.
PG  - 161-6
AB  - In Ewing sarcoma and related tumors, recently referred to as the Ewing tumors 
      (ET), t(11;22)(q24q12) and its molecular genetic equivalent, the EWS/FLI-1 
      rearrangement, characterize approximately 85% of cases, while variant aberrations 
      are rare. A second nonrandom aberration in ET is the unbalanced t(1;16) 
      accompanying the t(11;22) in roughly 17% of cases. We present a 17-year-old man 
      with estraosseous ET and multiple metastases, in whom the only cytogenetically 
      detectable chromosomal aberration was der (16)t(1;16)(q12;q11.2). This finding 
      was confirmed by fluorescence in situ hybridization (FISH). Using the RT-PCR 
      technique, a variant EWS/ERG fusion transcript was noted, resulting from a 
      t(21;22) chromosomal rearrangement which recently demonstrated in roughly 10% of 
      ET. However, data on possible biologic differences in EWS/FLI-1 versus EWS/ERG 
      expressing ET are as yet unavailable. This is the first reported combination of 
      t(1;16) with the EWS/ERG rearrangement. A possible significance of this finding 
      for Ewing tumor progression is discussed.
FAU - Stark, B
AU  - Stark B
AD  - Department of Pediatric Hematology/Oncology, Children's Medical Center of Israel, 
      Petah Tiqva, Israel.
FAU - Zoubek, A
AU  - Zoubek A
FAU - Hattinger, C
AU  - Hattinger C
FAU - Jeison, M
AU  - Jeison M
FAU - Gobuzov, R
AU  - Gobuzov R
FAU - Mor, C
AU  - Mor C
FAU - Cohen, I
AU  - Cohen I
FAU - Yaniv, I
AU  - Yaniv I
FAU - Ambros, P F
AU  - Ambros PF
FAU - Kovar, H
AU  - Kovar H
FAU - Zaizov, R
AU  - Zaizov R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - Bone Neoplasms/secondary
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 16
MH  - *Chromosomes, Human, Pair 22
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/secondary
MH  - Male
MH  - Sarcoma, Ewing/*genetics/pathology
MH  - *Translocation, Genetic
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 0165460895002049 [pii]
AID - 10.1016/0165-4608(95)00204-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Apr;87(2):161-6. doi: 10.1016/0165-4608(95)00204-9.