PMID- 8625369
OWN - NLM
STAT- MEDLINE
DCOM- 19960626
LR  - 20190909
IS  - 0340-7004 (Print)
IS  - 0340-7004 (Linking)
VI  - 42
IP  - 1
DP  - 1996 Jan
TI  - T cell receptor Vbeta repertoire of tumour-infiltrating lymphocytes in oral 
      squamous-cell carcinoma.
PG  - 69-70
AB  - Oral squamous cell carcinoma (OSCC) are frequently infiltrated by tumour 
      infiltrating lymphocytes (TILs) which may demonstrate specific anti-tumour 
      cytotoxicity. We have used a panel of family-specific primers in 
      reverse-transcriptase (RT)-polymerase chain reactions (PCR) to determine the TCR 
      Vbeta repertoire of TILs in the primary and metastatic tumours in patients with 
      OSCC. We observed a diverse and heterogenous usage of TCR Vbeta genes by TILs in 
      the primary tumours, a scenario not unlike normal oral mucosal lymphocytes. In 
      one patient with a longstanding history of OSCC, the repertoire was restricted. 
      Restricted TCR Vbeta gene usage also occurred in TILs of metastatic tumours. 
      Within individual patients, discrepancies of TCR Vbeta gene usage were also 
      observed between TILs in the primary OSCC and those in metastatic lymph nodes. 
      Work is ongoing to determine the clonality and functional significance of these 
      TILs.
FAU - Lim, S H
AU  - Lim SH
AD  - Department of Haematology, University of Wales College of Medicine, Heath Park, 
      UK.
FAU - Thomas, D W
AU  - Thomas DW
FAU - Coleman, S
AU  - Coleman S
FAU - Stephens, P
AU  - Stephens P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Cancer Immunol Immunother
JT  - Cancer immunology, immunotherapy : CII
JID - 8605732
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
MH  - Biopsy
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Humans
MH  - Lymph Nodes/pathology
MH  - Lymphocytes, Tumor-Infiltrating/*ultrastructure
MH  - Mouth Neoplasms/*pathology
MH  - Polymerase Chain Reaction/methods
MH  - Receptors, Antigen, T-Cell, alpha-beta/*analysis
MH  - Submandibular Gland
MH  - Transcription, Genetic
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1007/s002620050253 [doi]
PST - ppublish
SO  - Cancer Immunol Immunother. 1996 Jan;42(1):69-70. doi: 10.1007/s002620050253.