PMID- 8625548
OWN - NLM
STAT- MEDLINE
DCOM- 19960624
LR  - 20071115
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 104 Suppl 1
DP  - 1996 May
TI  - Intravenous immune globulin in the treatment of intractable childhood epilepsy.
PG  - 71-6
AB  - Many clinical and experimental data strongly support the role of immune 
      mechanisms in the pathogenesis of childhood epilepsy. Following Pechadre's first 
      observations with intramuscular immune globulin (IMIG), intravenous immune 
      globulin (IVIG) has been employed in some forms of intractable childhood epilepsy 
      (ICE), mainly in West syndrome (WS) and Lennox Gastaut syndrome (LGS), with good 
      results. So far, 373 children suffering from ICE have been treated in 29 studies 
      and 174 have responded favourably. Although these studies are heterogeneous and 
      controls are lacking, most authors report similar responsiveness ranging from 30% 
      to 50%. Several mechanisms have been suggested to account for the efficacy of 
      IVIG in ICE including antiviral effect, substitutive therapy in patients with 
      concomitant humoral immunodeficiency, idiotype-anti-idiotype interaction or a 
      neuromodulant effect. To better define the real efficacy of IVIG in ICE in 
      paediatric patients, a randomized, multicenter, double-blind clinical trial was 
      started in 1993, including only patients suffering from WS and LGS. To date, only 
      one double-blind trial had been carried out (with both adult and paediatric 
      patients); it showed a clear trend in favour of IVIG treatment but lacked 
      statistical significance, perhaps because of the small and heterogeneous sample. 
      Controlled multicentre studies on well-defined populations are needed and 
      patients with WS and LGS are probably the best candidates.
FAU - Duse, M
AU  - Duse M
AD  - Department of Pediatrics, University of Brescia, Italy.
FAU - Notarangelo, L D
AU  - Notarangelo LD
FAU - Tiberti, S
AU  - Tiberti S
FAU - Menegati, E
AU  - Menegati E
FAU - Plebani, A
AU  - Plebani A
FAU - Ugazio, A G
AU  - Ugazio AG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Controlled Clinical Trials as Topic
MH  - Double-Blind Method
MH  - Epilepsy/*therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Infant
MH  - Recurrence
RF  - 68
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
PST - ppublish
SO  - Clin Exp Immunol. 1996 May;104 Suppl 1:71-6.