PMID- 86267
OWN - NLM
STAT- MEDLINE
DCOM- 19790626
LR  - 20190716
IS  - 0001-5598 (Print)
IS  - 0001-5598 (Linking)
VI  - 90
IP  - 4
DP  - 1979 Apr
TI  - Hormone blood levels and their inter-relationships in normal men and men with 
      benign prostatic hyperplasia (BPH).
PG  - 727-36
AB  - In 128 non-hospitalized men (age range 36-65 years) rectal palpation revealed in 
      54 cases an enlargement of the prostate (group II), which was very distinct in 20 
      cases (group III). The measurement of testosterone (T), 
      5alpha-dihydrotestosterone (DHT), 5alpha-androstane-3alpha,17beta-diol 
      (3alpha-diol) oestradiol (Oe2), sex-hormone-binding-globulin binding capacity 
      (SHBG), luteinizing hormone (LH), follicle stimulating hormone (FSH) and 
      prolactin (Prl) in the blood of normal men (group I) and those with BPH (group II 
      or III) demonstrated no significant differences between the three groups when 
      respective age ranges were compared. A significant increase of FSH and decrease 
      of 3alpha-diol with age was seen in the normal group (I), which was similar but 
      less pronounced in BPH (groups II and III). A distinct increase of DHT with age 
      was found in BPH (group II), which was not so dominant in normal men (group I). 
      From these data it is concluded that the conversion of DHT to 3alpha-diol might 
      be reduced in older males independent from the occurrence of BPH and that the 
      hyperplastic prostate possibly secretes significant amounts of DHT into the 
      circulation. These results are discussed with respect to their possible role in 
      the pathogenesis of BPH.
FAU - Bartsch, W
AU  - Bartsch W
FAU - Becker, H
AU  - Becker H
FAU - Pinkenburg, F A
AU  - Pinkenburg FA
FAU - Krieg, M
AU  - Krieg M
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Acta Endocrinol (Copenh)
JT  - Acta endocrinologica
JID - 0370312
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Gonadotropins, Pituitary)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 25126-76-5 (Androstane-3,17-diol)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 9002-62-4 (Prolactin)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Androstane-3,17-diol/blood
MH  - Dihydrotestosterone/blood
MH  - Estradiol/blood
MH  - Follicle Stimulating Hormone/blood
MH  - Gonadal Steroid Hormones/*blood
MH  - Gonadotropins, Pituitary/*blood
MH  - Humans
MH  - Luteinizing Hormone/blood
MH  - Male
MH  - Middle Aged
MH  - Prolactin/blood
MH  - Prostatic Hyperplasia/*blood
MH  - Sex Hormone-Binding Globulin/analysis
MH  - Testosterone/blood
EDAT- 1979/04/01 00:00
MHDA- 1979/04/01 00:01
CRDT- 1979/04/01 00:00
PHST- 1979/04/01 00:00 [pubmed]
PHST- 1979/04/01 00:01 [medline]
PHST- 1979/04/01 00:00 [entrez]
AID - 10.1530/acta.0.0900727 [doi]
PST - ppublish
SO  - Acta Endocrinol (Copenh). 1979 Apr;90(4):727-36. doi: 10.1530/acta.0.0900727.