PMID- 8627176
OWN - NLM
STAT- MEDLINE
DCOM- 19960627
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 183
IP  - 2
DP  - 1996 Feb 1
TI  - The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural 
      killer cell receptors display highly homologous extracellular domains but differ 
      in their transmembrane and intracytoplasmic portions.
PG  - 645-50
AB  - Natural killer cells express clonally distributed receptors specific for major 
      histocompatibility complex class I molecules. The human leukocyte antigen 
      (HLA)-C-specific receptors have been molecularly identified and cloned. They 
      exist not only as inhibitory (p58) but also as activatory (p50) receptors. Here 
      we show that p50 and p58 are highly homologous in their extracellular regions 
      formed by two Ig-like domains. In contrast, major differences exist in their 
      transmembrane and cytoplasmic portions. Whereas p 58 displays a 76-84-amino acid 
      cytoplasmic tail containing an unusual antigen receptor activation motif, p50 is 
      characterized by a shorter 39-amino acid tail. In addition, whereas p58 has a 
      nonpolar transmembrane portion, p50 contains the charged amino acid Lys. These 
      data strongly suggest that receptors with identical HLA-C allele specificity can 
      mediate functions of opposite sign owing to their different 
      transmembrane/cytoplasmic portions.
FAU - Biassoni, R
AU  - Biassoni R
AD  - Istituto Nazionale per la Ricerca sul Cancro e Centro Biotecnologie Avanzate, 
      Genova, Italy.
FAU - Cantoni, C
AU  - Cantoni C
FAU - Falco, M
AU  - Falco M
FAU - Verdiani, S
AU  - Verdiani S
FAU - Bottino, C
AU  - Bottino C
FAU - Vitale, M
AU  - Vitale M
FAU - Conte, R
AU  - Conte R
FAU - Poggi, A
AU  - Poggi A
FAU - Moretta, A
AU  - Moretta A
FAU - Moretta, L
AU  - Moretta L
LA  - eng
SI  - GENBANK/X89892
SI  - GENBANK/X89893
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (DNA, Complementary)
RN  - 0 (HLA-C Antigens)
RN  - 0 (KIR2DL3 protein, human)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL3)
RN  - 0 (p50 natural killer cell receptor)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Clone Cells
MH  - DNA, Complementary/genetics
MH  - Flow Cytometry
MH  - HLA-C Antigens/*immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Molecular Sequence Data
MH  - Protein Conformation
MH  - Receptors, Immunologic/biosynthesis/*genetics
MH  - Receptors, KIR
MH  - Receptors, KIR2DL3
MH  - Sequence Homology, Amino Acid
MH  - *Signal Transduction
MH  - Structure-Activity Relationship
MH  - Transfection
PMC - PMC2192451
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
PMCR- 1996/08/01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
PHST- 1996/08/01 00:00 [pmc-release]
AID - 96195217 [pii]
AID - 10.1084/jem.183.2.645 [doi]
PST - ppublish
SO  - J Exp Med. 1996 Feb 1;183(2):645-50. doi: 10.1084/jem.183.2.645.