PMID- 8628094
OWN - NLM
STAT- MEDLINE
DCOM- 19960627
LR  - 20190825
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 106
IP  - 5 Pt 1
DP  - 1996 May
TI  - Brain-derived neurotrophic factor and peripheral nerve regeneration: a functional 
      evaluation.
PG  - 629-32
AB  - The potential benefit of brain-derived neurotrophic factor (BDNF) on motor-nerve 
      regeneration after transection injury in 24 adult rats was evaluated after 
      entubulation repair. Gait analysis for ankle angle and tension transduction 
      device (TTD) strain-gauge measurements yielded functional evaluation of 
      regeneration. The BDNF (15 mg/mL) or phosphate buffered saline (control) was 
      injected into the silicone elastomer (Silastic) channel. Gait analysis performed 
      0, 2, 4, 6, 10, and 12 weeks after injury demonstrated a significant difference 
      between uninjured and injured legs of 23 and 43 degrees, respectively (P<.001, 
      analysis of variance). The TTD evaluation 13 weeks after injury demonstrated a 
      significant decrease in force development of injured compared to uninjured legs, 
      148 and 58 g, respectively (P<.001). No functional benefits were demonstrated 
      between BDNF-treated versus control-treated animals in either model for a single 
      exposure to BDNF.
FAU - Shirley, D M
AU  - Shirley DM
AD  - Division of Otolaryngology, Southern Illinois University, Springfield, 62794, 
      USA.
FAU - Williams, S A
AU  - Williams SA
FAU - Santos, P M
AU  - Santos PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Female
MH  - Gait
MH  - Nerve Growth Factors/*pharmacology
MH  - Nerve Regeneration/*drug effects
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Peroneal Nerve/drug effects/injuries/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1097/00005537-199605000-00021 [doi]
PST - ppublish
SO  - Laryngoscope. 1996 May;106(5 Pt 1):629-32. doi: 10.1097/00005537-199605000-00021.