PMID- 8630973
OWN - NLM
STAT- MEDLINE
DCOM- 19960701
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 88
IP  - 1
DP  - 1996 May
TI  - Cytogenetic and histologic correlation of peripheral nerve sheath tumors of soft 
      tissue.
PG  - 17-25
AB  - Cytogenetic analysis was performed on 11 peripheral nerve sheath tumors of soft 
      tissue from 10 patients. They include 6 benign and 5 malignant schwannomas. Five 
      cases which include two benign, one cellular and two malignant schwannomas had a 
      known association with a nerve, but only one patient with malignant schwannoma 
      has clinically documented neurofibromatosis type I. All the patients had a normal 
      diploid constitutional karyotype. Two cases of cellular schwannoma were analyzed 
      by routine cytogenetic analysis and fluorescence in situ hybridization (FISH). 
      One tumor was karyotyped as 45, XX,-13,-22 +mar; and the other case had a 
      45,X,-Y,t(1;17) (p12;q11.2) karyotype. In the latter, the breakpoint in 17q 
      occurred below the centromere and is at or in the region of the Neurofibromatosis 
      Type 1 (NF1) gene. Four benign tumors had a normal diploid karyotype. One 
      hypodiploid malignant schwannoma with myxoid features demonstrated monosomy of 
      chromosomes 17 and 22 by FISH analysis. The rest of the malignant schwannomas 
      showed a wide range of numerical and structural aberrations, with frequent loss 
      of 22q and gains of chromosomes 2 and 7. Loss of a sex chromosome was observed in 
      cellular as well as malignant schwannomas. Regional karyotypic evolution was 
      noted in one malignant schwannoma. Cytogenetic analysis may prove to be useful in 
      identifying tumors, such as cellular schwannomas, which, because of their 
      histologic features may be inadvertently categorized as malignant. Simultaneous 
      involvement of NF1 and NF2 genes, which are located on chromosomes 17q and 22q, 
      respectively, should be investigated at a molecular level in both benign and 
      malignant tumors of peripheral nerves.
FAU - Rao, U N
AU  - Rao UN
AD  - Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania, 
      15213-2582, USA.
FAU - Surti, U
AU  - Surti U
FAU - Hoffner, L
AU  - Hoffner L
FAU - Yaw, K
AU  - Yaw K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 22
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Neurilemmoma/genetics/pathology
MH  - Neurofibromatosis 1/genetics/pathology
MH  - Peripheral Nervous System Neoplasms/*genetics/*pathology
MH  - Soft Tissue Neoplasms/*genetics/*pathology
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 0165460895002812 [pii]
AID - 10.1016/0165-4608(95)00281-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 May;88(1):17-25. doi: 10.1016/0165-4608(95)00281-2.