PMID- 8631881
OWN - NLM
STAT- MEDLINE
DCOM- 19960701
LR  - 20210210
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 271
IP  - 18
DP  - 1996 May 3
TI  - A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in 
      developing nervous system and pituitary gland.
PG  - 10723-30
AB  - A screen designed to identify proteins that specifically bind to retinoic acid 
      response elements resulted in the identification of a rat cDNA encoding a novel 
      protein containing six Cys-Cys, His-Cys zinc fingers. This gene is expressed in a 
      restricted fashion exhibiting distinct temporal and spatial patterns in the 
      developing nervous system, primarily brain, spinal cord, sensory ganglia, retina, 
      and nasal epithelia, as well as in the pituitary, and is referred to as neural 
      zinc finger factor 1 (NZF-1). NZF-1 binds specifically to a cis-regulatory 
      element of the beta-retinoic acid receptor (RAR beta) gene, as well as to other 
      related DNA elements, including two in the upstream enhancer region of the mouse 
      Pit-1 gene. In heterologous cells, NZF-1 activates transcription from promoters 
      containing specific binding sequences and can synergize with other factors, such 
      as Pit-1, to regulate gene expression. These results suggest that NZF-1 may exert 
      regulatory roles in the developing and mature nervous system and in the pituitary 
      gland. Identification of a second mouse gene highly homologous to NZF-1, encoded 
      by a distinct genomic locus, reveals a dispersed gene family encoding proteins 
      containing Cys-Cys, His-Cys motifs.
FAU - Jiang, Y
AU  - Jiang Y
AD  - Department of Medicine, Howard Hughes Medical Institute, La Jolla, California, 
      USA.
FAU - Yu, V C
AU  - Yu VC
FAU - Buchholz, F
AU  - Buchholz F
FAU - O'Connell, S
AU  - O'Connell S
FAU - Rhodes, S J
AU  - Rhodes SJ
FAU - Candeloro, C
AU  - Candeloro C
FAU - Xia, Y R
AU  - Xia YR
FAU - Lusis, A J
AU  - Lusis AJ
FAU - Rosenfeld, M G
AU  - Rosenfeld MG
LA  - eng
SI  - GENBANK/U48809
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Myt1l protein, rat)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 4QD397987E (Histidine)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cysteine/genetics
MH  - DNA, Complementary
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Histidine/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Nerve Tissue Proteins/*genetics/metabolism
MH  - Nervous System/embryology/*metabolism
MH  - Pituitary Gland/embryology/*metabolism
MH  - RNA Splicing
MH  - Rats
MH  - Sequence Homology, Amino Acid
MH  - Trans-Activators/*genetics/metabolism
MH  - Transcription Factors/*genetics/metabolism
MH  - Zinc Fingers/*genetics
EDAT- 1996/05/03 00:00
MHDA- 1996/05/03 00:01
CRDT- 1996/05/03 00:00
PHST- 1996/05/03 00:00 [pubmed]
PHST- 1996/05/03 00:01 [medline]
PHST- 1996/05/03 00:00 [entrez]
AID - S0021-9258(18)98068-3 [pii]
AID - 10.1074/jbc.271.18.10723 [doi]
PST - ppublish
SO  - J Biol Chem. 1996 May 3;271(18):10723-30. doi: 10.1074/jbc.271.18.10723.