PMID- 8632358
OWN - NLM
STAT- MEDLINE
DCOM- 19960703
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 276
IP  - 2
DP  - 1996 Feb
TI  - Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial 
      recovery over a 52-week period. Part I: Synaptosomal uptake and tissue 
      concentrations.
PG  - 846-54
AB  - The effects of a high dose methylenedioxymethamphetamine (MDMA) regimen on the 
      serotonin (5-HT) system were evaluated over a 52-wk period. MDMA was administered 
      to rats (20 mg/kg) 8 times at 12-hr intervals. Tissue concentrations of dopamine 
      (DA) and 5-HT, and synaptosomal uptake of 3H-5-HT and 3H-DA were measured at 2, 
      8, 16, 32 or 52 wk posttreatment. Synaptosomal uptake of 3H-5-HT (hippocampus) 
      was decreased at 2 and 8 wk, but not at 16, 32 or 52 wk after drug. 5-HT tissue 
      concentrations were measured in frontal cortex, frontal-parietal cortex, 
      occipital-temporal cortex, nucleus accumbens/olfactory tubercle, striatum, 
      amygdala, hippocampus, septum, hypothalamus, ventral tegmentum/substantia nigra. 
      Two weeks after MDMA treatment, all regions showed decreased 5-HT tissue 
      concentrations except septum. Recovery over the 52-wk interval was noted for all 
      depleted regions, but the rate and degree of recovery was region dependent. 
      Frontal-parietal cortex, occipital-temporal cortex and hippocampus showed the 
      least recovery, with significant depletions at 52 wk posttreatment. Hypothalamus 
      showed an increase in 5-HT tissue concentrations relative to age-matched controls 
      at 52 wk. These results indicate that a high-dose MDMA regimen results in 
      long-lasting depletions of serotonin. The rate and degree of recovery of 
      serotonin tissue concentrations seen over the 52-wk test period is region 
      specific.
FAU - Sabol, K E
AU  - Sabol KE
AD  - University of Chicago, Department of Pharmacological and Physiological Sciences, 
      Illinois, USA.
FAU - Lew, R
AU  - Lew R
FAU - Richards, J B
AU  - Richards JB
FAU - Vosmer, G L
AU  - Vosmer GL
FAU - Seiden, L S
AU  - Seiden LS
LA  - eng
GR  - DA-00085/DA/NIDA NIH HHS/United States
GR  - RSA 10562/RS/DRS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain Chemistry/*drug effects
MH  - Dopamine/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/analysis/*metabolism
MH  - Serotonin Agents/*toxicity
MH  - Synaptosomes/*metabolism
MH  - Time Factors
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1996 Feb;276(2):846-54.