PMID- 8634048
OWN - NLM
STAT- MEDLINE
DCOM- 19960701
LR  - 20190718
IS  - 0004-8682 (Print)
IS  - 0004-8682 (Linking)
VI  - 66
IP  - 5
DP  - 1996 May
TI  - P53 tumour suppressor gene expression in hyperparathyroidism.
PG  - 302-4
AB  - BACKGROUND: Mutations of the p53 tumour suppressor gene lead to the loss of 
      control of normal cellular proliferation and differentiation and have been shown 
      to be associated with the development of malignancy. METHOD: Archival paraffin 
      resection specimens from 86 cases of hyperparathyroidism treated surgically using 
      the rabbit polyclonal CMI antibody were investigated to detect p53 
      immunoreactivity in these sections. RESULTS: Eighteen of the 86 sections examined 
      (21%) showed nuclear immunoreactivity. No correlation was detected between tumour 
      histology and p53 immunoreactivity (P = 0.45), nor was there any correlation 
      between tumour clonality and immunoreactivity (P = 0.54). Multiple endocrine 
      neoplasia type 1 (MEN 1) status did not correlate with p53 immunoreactivity. A 
      significant correlation between p53 immunoreactivity and preparathyroidectomy 
      calcium levels of > 1.5 mmol/L was detected (P < 0.005) although no correlation 
      was noted between p53 immunoreactivity and higher levels of preparathyroidectomy 
      intact parathyroid hormone (PTH) levels. CONCLUSION: A relationship is postulated 
      between abnormal serum calcium regulation and p53 mutation in hypercalcaemic 
      states associated with hyperparathyroidism.
FAU - Subramaniam, P
AU  - Subramaniam P
AD  - University Department of Surgery, University of Tasmania, Hobart, Australia.
FAU - Wilkinson, S
AU  - Wilkinson S
FAU - Shepherd, J J
AU  - Shepherd JJ
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust N Z J Surg
JT  - The Australian and New Zealand journal of surgery
JID - 0373115
RN  - 0 (Parathyroid Hormone)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium/blood
MH  - *Genes, p53
MH  - Humans
MH  - Hyperparathyroidism/*genetics/pathology/surgery
MH  - Hyperplasia
MH  - Immunohistochemistry
MH  - Multiple Endocrine Neoplasia Type 1/genetics
MH  - Parathyroid Glands/pathology
MH  - Parathyroid Hormone/blood
MH  - Parathyroid Neoplasms/genetics
MH  - Parathyroidectomy
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1111/j.1445-2197.1996.tb01191.x [doi]
PST - ppublish
SO  - Aust N Z J Surg. 1996 May;66(5):302-4. doi: 10.1111/j.1445-2197.1996.tb01191.x.