PMID- 8634691
OWN - NLM
STAT- MEDLINE
DCOM- 19960708
LR  - 20190512
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 4
IP  - 12
DP  - 1995 Dec
TI  - Non-disjunction in human sperm: evidence for an effect of increasing paternal 
      age.
PG  - 2227-32
AB  - In humans, the relationship between advancing maternal age and the incidence of 
      trisomy has been long established, but the possible effect of increasing age of 
      the father remains controversial. Using a fluorescence in situ hybridization 
      (FISH) approach to directly examine individual sperm for aneuploidy of the sex 
      chromosomes and chromosome 18, we have analyzed approximately 400,000 sperm from 
      24 men aged 18-60 years. There was no obvious relationship between increasing age 
      and disomy 18, but the incidence of XY,YY and XX disomy all were significantly 
      elevated among older men. This suggests that older men, like older women, have an 
      increased likelihood of producing aneuploid offspring by comparison with their 
      younger counterparts.
FAU - Griffin, D K
AU  - Griffin DK
AD  - Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, 
      USA.
FAU - Abruzzo, M A
AU  - Abruzzo MA
FAU - Millie, E A
AU  - Millie EA
FAU - Sheean, L A
AU  - Sheean LA
FAU - Feingold, E
AU  - Feingold E
FAU - Sherman, S L
AU  - Sherman SL
FAU - Hassold, T J
AU  - Hassold TJ
LA  - eng
GR  - HD21341/HD/NICHD NIH HHS/United States
GR  - HD32111/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aneuploidy
MH  - Chromosomes, Human, Pair 18
MH  - Diploidy
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - *Nondisjunction, Genetic
MH  - *Paternal Age
MH  - Spermatozoa/*ultrastructure
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1093/hmg/4.12.2227 [doi]
PST - ppublish
SO  - Hum Mol Genet. 1995 Dec;4(12):2227-32. doi: 10.1093/hmg/4.12.2227.