PMID- 8635138
OWN - NLM
STAT- MEDLINE
DCOM- 19960709
LR  - 20220310
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 77
IP  - 6
DP  - 1996 Mar 15
TI  - The correlation between the loss of chromosome 14q with histologic tumor grade, 
      pathologic stage, and outcome of patients with nonpapillary renal cell carcinoma.
PG  - 1154-60
AB  - BACKGROUND: Conventional pathologic classifications of human renal cell carcinoma 
      (RCC) give little insight into oncogenesis and little assistance in predicting 
      the clinical behavior of this disease. Identification of specific genetic 
      alterations involved in the development of RCC using fluorescence in situ 
      hybridization (FISH) however, may help provide foundations for classification, 
      prognosis, and clinical management of the patients. METHODS: Archival, paraffin 
      embedded tissue sections from 30 human non-papillary RCCs were examined with a 
      dual color FISH technique for loss of chromosomes 3p and 14q. Telomeric DNA 
      probes from 3p or 14q and an internal ploidy control probe, centromeric probe of 
      chromosome 2, were applied directly to the tumor sections. The correlations 
      between loss of 3p or 14q, and tumor ploidy, with tumor grade, pathologic stage, 
      and patient outcome were assessed. RESULTS: Ninety percent of the patients (27) 
      lost chromosome 3p, and 36.7% of the patients (11) had chromosome 14q deletions. 
      The loss of 3p in the samples tested was unrelated to patient age, gender, 
      outcome, tumor stage, or histologic grade. However, the deletion of 14q was 
      significantly correlated with higher stage (P = 0.01), histologic grade (P = 
      0.01), and patient outcome (P < 10(-4)). CONCLUSION: The close correlation of 14q 
      loss with higher stage, higher histologic grade, and poorer outcome for patients 
      with nonpapillary RCC indicates that it may be a promising prognostic marker.
FAU - Wu, S Q
AU  - Wu SQ
AD  - Cytogenetic Research Laboratory, Comprehensive Cancer Center, University of 
      Wisconsin, Madison, USA.
FAU - Hafez, G R
AU  - Hafez GR
FAU - Xing, W
AU  - Xing W
FAU - Newton, M
AU  - Newton M
FAU - Chen, X R
AU  - Chen XR
FAU - Messing, E
AU  - Messing E
LA  - eng
GR  - CA 14520/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Renal Cell/*genetics/mortality/*pathology
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 3
MH  - Female
MH  - Humans
MH  - Kidney Neoplasms/*genetics/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Ploidies
MH  - Prognosis
MH  - Sex Factors
EDAT- 1996/03/15 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/03/15 00:00
PHST- 1996/03/15 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/03/15 00:00 [entrez]
AID - 10.1002/(SICI)1097-0142(19960315)77:6<1154::AID-CNCR23>3.0.CO;2-# [pii]
AID - 10.1002/(sici)1097-0142(19960315)77:6<1154::aid-cncr23>3.0.co;2-# [doi]
PST - ppublish
SO  - Cancer. 1996 Mar 15;77(6):1154-60. doi: 
      10.1002/(sici)1097-0142(19960315)77:6<1154::aid-cncr23>3.0.co;2-#.