PMID- 8636314
OWN - NLM
STAT- MEDLINE
DCOM- 19960708
LR  - 20111117
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 81
IP  - 2
DP  - 1996 Feb
TI  - Lack of an independent association between the human leukocyte antigen allele 
      DQA1*0501 and Graves' disease.
PG  - 847-9
AB  - The association between the human leukocyte antigen (HLA) serotype DR3 and 
      Graves' disease (GD) in Caucasian populations is well known. However, an even 
      stronger association has been reported recently, especially in the male 
      population, between the closely linked HLA allele DQA1*0501 and GD. We postulated 
      that the reported association between DQA1*0501 and GD may be a result of the 
      linkage of this allele with DR3 and may not represent an independent association. 
      Accordingly, we screened a population of North American Caucasians (n = 218), 
      including patients with GD (n = 101, 32 males, 69 females) and individuals with 
      documented normal thyroid function (n = 117, 51 males, 66 females), for the 
      presence of the DQA1*0501 allele and those alleles corresponding to the DR3 
      serotype (DRB1*03). Screening was accomplished using sequence specific PCR. A 
      significant association was documented in the total study population between DR3 
      positivity and GD (P = 0.0002), but not between DQA1*0501 positivity and GD (P = 
      0.06). After gender stratification, significant associations were found only in 
      the female population (DR3, P = 0.0004; DQA1*0501, P = 0.012) and not in the male 
      population (DR3, P = 1.0; DQA1*0501, P = 1.0). Additionally, in those DR3 
      negative female subjects (n = 100), there was no independent association between 
      DQA1*0501 positivity (n = 26) and GD (p = 0.82). P-values were corrected, where 
      appropriate, for gender stratification and/or the number of HLA alleles tested. 
      In conclusion, our results demonstrate a lack of independent association between 
      the presence of the HLA allele DQA1*0501 and GD. We suggest that the apparent 
      association between this allele and GD in the female population may be the result 
      of its' close linkage to DR3.
FAU - Cuddihy, R M
AU  - Cuddihy RM
AD  - Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 
      55905, USA.
FAU - Bahn, R S
AU  - Bahn RS
LA  - eng
GR  - EYO8819/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DR3 Antigen)
SB  - IM
MH  - Alleles
MH  - Base Sequence
MH  - Female
MH  - Graves Disease/genetics/*immunology
MH  - HLA-DQ Antigens/*analysis/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DR3 Antigen/analysis/genetics
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 10.1210/jcem.81.2.8636314 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1996 Feb;81(2):847-9. doi: 10.1210/jcem.81.2.8636314.