PMID- 8638693
OWN - NLM
STAT- MEDLINE
DCOM- 19960705
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 270
IP  - 3 Pt 1
DP  - 1996 Mar
TI  - Increments in skeletal muscle GLUT-1 and GLUT-4 after endurance training in 
      humans.
PG  - E456-62
AB  - We investigated the time course of training-induced changes in the expression of 
      GLUT-1 and GLUT-4 in human skeletal muscle. Seven healthy males trained for 2 
      h/day (approximately 60% pretraining VO2peak) for 31 days (31D). Muscle biopsies 
      were obtained before training (PRE) and after 5 (5D) and 31 days (31D) of 
      training. Training resulted in progressive increases in muscle GLUT-4 with 
      increasing training duration (PRE<5D<31D; P<0.01). Muscle GLUT-1 content was also 
      increased (P<0.05) after training; however, the increase was not observed until 
      31D (131%). Increases in muscle hexokinase (HK) activity were complete by 5D 
      (P<0.01). Muscle malate dehydrogenase activity was not elevated after 5D of 
      training but was increased (+35%; P<0.01) at 31D. Results from this study show 
      that increases in both GLUT-4 and HK represent early training-induced adaptations 
      to prolonged exercise training. As training progresses, further increases in 
      GLUT-4, but not HK, occur in conjunction with an increase in muscle mitochondrial 
      potential and GLUT-1.
FAU - Phillips, S M
AU  - Phillips SM
AD  - Department of Kinesiology, University of Waterloo, Ontario, Canada.
FAU - Han, X X
AU  - Han XX
FAU - Green, H J
AU  - Green HJ
FAU - Bonen, A
AU  - Bonen A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Glucose Transporter Type 1)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Monosaccharide Transport Proteins)
RN  - 0 (Muscle Proteins)
RN  - 0 (SLC2A1 protein, human)
RN  - 0 (SLC2A4 protein, human)
RN  - EC 1.1.1.37 (Malate Dehydrogenase)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Exercise
MH  - Glucose Transporter Type 1
MH  - Glucose Transporter Type 4
MH  - Hexokinase/metabolism
MH  - Humans
MH  - Malate Dehydrogenase/metabolism
MH  - Male
MH  - Monosaccharide Transport Proteins/*metabolism
MH  - *Muscle Proteins
MH  - Muscle, Skeletal/cytology/*physiology
MH  - *Physical Endurance
MH  - Regression Analysis
MH  - Time Factors
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.1152/ajpendo.1996.270.3.E456 [doi]
PST - ppublish
SO  - Am J Physiol. 1996 Mar;270(3 Pt 1):E456-62. doi: 10.1152/ajpendo.1996.270.3.E456.