PMID- 8638700
OWN - NLM
STAT- MEDLINE
DCOM- 19960705
LR  - 20221207
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 270
IP  - 3 Pt 1
DP  - 1996 Mar
TI  - Neuroendocrine and cardiovascular effects of serotonin: selective role of brain 
      angiotensin on vasopressin.
PG  - E513-21
AB  - Central serotonin (5-HT) and angiotensin (ANG II) stimulate arginine vasopressin 
      (AVP), oxytocin (OT), and adrenocorticotropin (ACTH) secretion and increase blood 
      pressure. Studies were conducted in conscious rats to determine whether 
      neuroendocrine activation by 5-HT requires a brain angiotensinergic intermediate 
      pathway. In the first study, ANG II formation was inhibited by the 
      angiotensin-converting enzyme inhibitor enalapril before injection of the 5-HT 
      releaser/uptake inhibitor d-fenfluramine. Fenfluramine (2 mg/kg ip) stimulated 
      AVP, OT, corticosterone, and prolactin (PRL) secretion (P<0.01). Enalapril (60 
      mg/l in drinking water for 4 days and 10 mg/kg ip 2 h before the rats were 
      killed) inhibited only the AVP response (P<0.01) to d-fenfluramine. In the second 
      study, the effect of intracerebroventricular injection of the 5-HT2A/2C 
      antagonist LY-53857 (10 microgram), or the ANG II AT1 antagonist DuP-753 (10 
      microgram), on intracerebroventricular 5-HT (10 microgram)-stimulated AVP, OT, 
      ACTH, PRL, renin secretion, mean arterial pressure (MAP) and heart rate (HR) was 
      tested. LY-53857 inhibited the AVP, OT, and ACTH responses to 5-HT (P<0.01), 
      whereas DuP-753 inhibited only the AVP response (P<0.01). Intraventricular 
      injection of 5-HT increased MAP and decreased HR. The MAP response was not 
      affected by LY-53857 or DuP-753, and at no time did MAP decline below starting 
      levels. The decreased HR was inhibited by LY-53857 but not by DuP-753. These 
      results demonstrate that 5-HT-induced AVP secretion is mediated selectively via 
      brain angiotensinergic mechanisms by way of the AT1 receptor.
FAU - Saydoff, J A
AU  - Saydoff JA
AD  - Department of Comparative Biosciences, Schools of Veterinary Medicine, University 
      of Wisconsin, Madison 53706, USA.
FAU - Rittenhouse, P A
AU  - Rittenhouse PA
FAU - Carnes, M
AU  - Carnes M
FAU - Armstrong, J
AU  - Armstrong J
FAU - Van De Kar, L D
AU  - Van De Kar LD
FAU - Brownfield, M S
AU  - Brownfield MS
LA  - eng
GR  - MH-45812/MH/NIMH NIH HHS/United States
GR  - R29-DK-40759/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Ergolines)
RN  - 0 (Imidazoles)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0 (Tetrazoles)
RN  - 11128-99-7 (Angiotensin II)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 2DS058H2CF (Fenfluramine)
RN  - 333DO1RDJY (Serotonin)
RN  - 50-56-6 (Oxytocin)
RN  - 69PN84IO1A (Enalapril)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9002-62-4 (Prolactin)
RN  - EC 3.4.23.15 (Renin)
RN  - JMS50MPO89 (Losartan)
RN  - L37TVX7U5M (LY 53857)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/metabolism
MH  - Analysis of Variance
MH  - Angiotensin II/*pharmacology/*physiology
MH  - Angiotensin-Converting Enzyme Inhibitors/pharmacology
MH  - Animals
MH  - Antihypertensive Agents/administration & dosage/pharmacology
MH  - Arginine Vasopressin/*metabolism
MH  - Biphenyl Compounds/administration & dosage/pharmacology
MH  - Blood Pressure/*drug effects
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Corticosterone/metabolism
MH  - Enalapril/*pharmacology
MH  - Ergolines/administration & dosage/pharmacology
MH  - Fenfluramine/pharmacology
MH  - Heart Rate/*drug effects
MH  - Imidazoles/administration & dosage/pharmacology
MH  - Injections, Intraventricular
MH  - Losartan
MH  - Male
MH  - Oxytocin/metabolism
MH  - Prolactin/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Renin/blood
MH  - Serotonin/*pharmacology/*physiology
MH  - Serotonin Antagonists/administration & dosage/pharmacology
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
MH  - Tetrazoles/administration & dosage/pharmacology
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.1152/ajpendo.1996.270.3.E513 [doi]
PST - ppublish
SO  - Am J Physiol. 1996 Mar;270(3 Pt 1):E513-21. doi: 10.1152/ajpendo.1996.270.3.E513.