PMID- 8639129
OWN - NLM
STAT- MEDLINE
DCOM- 19960705
LR  - 20190718
IS  - 0004-8682 (Print)
IS  - 0004-8682 (Linking)
VI  - 66
IP  - 3
DP  - 1996 Mar
TI  - The prevalence of MEN-1 in Tasmania.
PG  - 141-3
AB  - BACKGROUND: An extensive programme was undertaken to trace and screen four known 
      families in Tasmania with multiple endocrine neoplasia type 1 (MEN-1). METHODS: 
      Written and personal contact was made with family members over the age of 20 
      years recommending a review by family practitioners for the purpose of recording 
      their medical history and collecting a blood sample. Those suspected of MEN-1 
      were referred to our Department for further investigation. RESULTS: In January 
      1993, the total number of individuals alive and known to be affected by MEN-1 was 
      107, giving a prevalence of MEN-1 disease in Tasmania of 23/100 000. The 
      estimated prevalence of MEN-1 trait in Tasmania (including affected cases and 
      those considered at 50% risk of possessing the trait) is 45/100 000. CONCLUSION: 
      The prevalence of MEN-1 has never previously been determined accurately. The 
      prevalence of MEN-1 in Tasmania is at the upper end of the possible range and 
      would justify the allocation of resources for screening programmes equal to those 
      available for the detection of several less prevalent genetic diseases.
FAU - Wilkinson, S
AU  - Wilkinson S
AD  - Department of Surgery, University of Tasmania, Hobart, Australia.
FAU - Young, M
AU  - Young M
FAU - Shepherd, J J
AU  - Shepherd JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Aust N Z J Surg
JT  - The Australian and New Zealand journal of surgery
JID - 0373115
RN  - 0 (Bicarbonates)
RN  - 0 (Chlorides)
RN  - 0 (Phosphates)
RN  - 0 (Serum Albumin)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alkaline Phosphatase/blood
MH  - Bicarbonates/blood
MH  - Calcium/blood
MH  - Child
MH  - Chlorides/blood
MH  - Follow-Up Studies
MH  - Health Care Rationing
MH  - Humans
MH  - Mass Screening
MH  - Medical History Taking
MH  - Multiple Endocrine Neoplasia Type 1/blood/*epidemiology/genetics/prevention & 
      control
MH  - Phosphates/blood
MH  - Prevalence
MH  - Risk Factors
MH  - Serum Albumin/analysis
MH  - Tasmania/epidemiology
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.1111/j.1445-2197.1996.tb01142.x [doi]
PST - ppublish
SO  - Aust N Z J Surg. 1996 Mar;66(3):141-3. doi: 10.1111/j.1445-2197.1996.tb01142.x.