PMID- 8639438
OWN - NLM
STAT- MEDLINE
DCOM- 19960715
LR  - 20131121
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 93
IP  - 2
DP  - 1996 May
TI  - BCR rearrangement without juxtaposition of ABL in pre-T acute lymphoblastic 
      leukaemia.
PG  - 403-5
AB  - The incidence and clinical relevance of the Philadelphia (Ph) translocation 
      t(9:22) (q34:q11) in T-lineage acute lymphoblastic leukaemia (ALL) are unknown. 
      We describe a patient with pre-T-ALL and a clonal 22q-aberration detected by 
      conventional cytogenetics, suggestive of a Ph translocation. However, 
      fluorescence in situ hybridization (FISH) using BCR and ABL probes revealed a 
      translocation with one breakpoint within the BCR gene on chromosome 22 without 
      juxtaposition of ABL on chromosome 9. We discuss the diagnostic and possible 
      pathogenetic implications of this Ph-like chromosomal aberration.
FAU - Fossa, A
AU  - Fossa A
AD  - Department of Internal Medicine (Cancer Research), University Hospital of Essen, 
      Germany.
FAU - Siebert, R
AU  - Siebert R
FAU - Kasper, C
AU  - Kasper C
FAU - Becher, R
AU  - Becher R
FAU - Opalka, B
AU  - Opalka B
FAU - Thiel, E
AU  - Thiel E
FAU - Seeber, S
AU  - Seeber S
FAU - Nowrousian, M R
AU  - Nowrousian MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - *Chromosomes, Human, Pair 22
MH  - *Chromosomes, Human, Pair 9
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia-Lymphoma, Adult T-Cell/*genetics
MH  - Philadelphia Chromosome
MH  - Polymerase Chain Reaction
MH  - Preleukemia/*genetics
MH  - *Translocation, Genetic
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
PST - ppublish
SO  - Br J Haematol. 1996 May;93(2):403-5.