PMID- 8640042
OWN - NLM
STAT- MEDLINE
DCOM- 19960715
LR  - 20190821
IS  - 0803-5253 (Print)
IS  - 0803-5253 (Linking)
VI  - 85
IP  - 2
DP  - 1996 Feb
TI  - Interleukin-1 alpha and interleukin-1 receptor antagonist in the urine of 
      children with acute pyelonephritis and relation to renal scarring.
PG  - 158-62
AB  - Urinary concentrations of interleukin-1 alpha (IL-1 alpha) and interleukin-1 
      receptor antagonist (IL-lra) standardized to urinary creatinine concentrations 
      were studied. The median standardized IL-1 alpha creatinine quotient in children 
      with first-time acute pyelonephritis was 3.6 pg/mumol, but was nondetectable in 
      children with recurrent pyelonephritis, children with non-renal febrile 
      conditions and children convalescent after acute pyelonephritis (p < 0.05-0.01). 
      IL-lra levels were also significantly higher in children with acute first-time 
      pyelonephritis (median of 239 pg/mumol) compared to these three groups of 
      children (p < 0.01-0.001). The highest urinary IL-lra levels, however, were found 
      in the healthy controls (median value 1.019; p < 0.001). Both cytokines were 
      higher among children younger than one year compared to older children. The acute 
      IL-1 alpha creatinine quotients were lowest in children with uptake defects on 
      99mTC-dimercaptosuccinic acid (DMSA) scintigraphy both during the acute infection 
      (reflecting the acute inflammation) (p < 0.001) and 1 year after the acute 
      infection (reflecting permanent kidney scarring) (p < 0.001). In conclusion, 
      persisting high urinary levels of IL-1 alpha were associated with less renal 
      inflammation and scarring.
FAU - Tullus, K
AU  - Tullus K
AD  - Department of Pediatrics, St Goran's Children's Hospital, Stockholm, Sweden.
FAU - Escobar-Billing, R
AU  - Escobar-Billing R
FAU - Fituri, O
AU  - Fituri O
FAU - Burman, L G
AU  - Burman LG
FAU - Karlsson, A
AU  - Karlsson A
FAU - Wikstad, I
AU  - Wikstad I
FAU - Wretlind, B
AU  - Wretlind B
FAU - Brauner, A
AU  - Brauner A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Interleukin-1)
RN  - 0 (Receptors, Interleukin-1)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Acute Disease
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Cicatrix/*physiopathology
MH  - Creatinine/urine
MH  - Humans
MH  - Infant
MH  - Interleukin-1/*urine
MH  - Kidney/*physiopathology
MH  - Pyelonephritis/*physiopathology/*urine
MH  - Receptors, Interleukin-1/*antagonists & inhibitors
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 10.1111/j.1651-2227.1996.tb13984.x [doi]
PST - ppublish
SO  - Acta Paediatr. 1996 Feb;85(2):158-62. doi: 10.1111/j.1651-2227.1996.tb13984.x.