PMID- 8640222
OWN - NLM
STAT- MEDLINE
DCOM- 19960716
LR  - 20220129
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 13
IP  - 2
DP  - 1996 Jun
TI  - Identification and mapping of human cDNAs homologous to Drosophila mutant genes 
      through EST database searching.
PG  - 167-74
AB  - Cross-species comparison is an effective tool used to identify genes and study 
      their function in both normal and pathological conditions. We have applied the 
      power of Drosophila genetics to the vast resource of human cDNAs represented in 
      the expressed sequence tag (EST) database (dbEST) to identify novel human genes 
      of high biological interest. Sixty-six human cDNAs showing significant homology 
      to genes causing Drosophila mutant phenotypes were identified by screening dbEST 
      using the "text string' option, and their map position was determined using both 
      fluorescence in situ hybridization (FISH) and radiation hybrid mapping. 
      Comparison between these genes and their putative partners in Drosophila may 
      provide important insights into their function in mammals. Furthermore, 
      integration of these genes into the transcription map of the human genome 
      contributes to the positional candidate approach for disease gene identification.
FAU - Banfi, S
AU  - Banfi S
AD  - Telethon Institute of Genetics and Medicine (TIGEM) Milan, Italy.
FAU - Borsani, G
AU  - Borsani G
FAU - Rossi, E
AU  - Rossi E
FAU - Bernard, L
AU  - Bernard L
FAU - Guffanti, A
AU  - Guffanti A
FAU - Rubboli, F
AU  - Rubboli F
FAU - Marchitiello, A
AU  - Marchitiello A
FAU - Giglio, S
AU  - Giglio S
FAU - Coluccia, E
AU  - Coluccia E
FAU - Zollo, M
AU  - Zollo M
FAU - Zuffardi, O
AU  - Zuffardi O
FAU - Ballabio, A
AU  - Ballabio A
LA  - eng
SI  - GENBANK/G30939
SI  - GENBANK/G30940
SI  - GENBANK/G31158
SI  - GENBANK/G31159
SI  - GENBANK/G31160
SI  - GENBANK/G31161
SI  - GENBANK/G31203
SI  - GENBANK/G31204
GR  - TGM06S01/TI_/Telethon/Italy
GR  - TGM94000/TI_/Telethon/Italy
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (DNA, Complementary)
SB  - IM
CIN - Nat Genet. 1996 Jun;13(2):133-4. PMID: 8640210
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosome Mapping/*methods
MH  - Computer Communication Networks
MH  - DNA, Complementary
MH  - *Databases, Factual
MH  - Drosophila melanogaster/*genetics
MH  - Genes, Insect
MH  - Humans
MH  - Hybrid Cells/radiation effects
MH  - In Situ Hybridization, Fluorescence
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phenotype
MH  - Sequence Alignment/methods
MH  - Sequence Homology, Amino Acid
MH  - *Sequence Homology, Nucleic Acid
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 10.1038/ng0696-167 [doi]
PST - ppublish
SO  - Nat Genet. 1996 Jun;13(2):167-74. doi: 10.1038/ng0696-167.