PMID- 8640721
OWN - NLM
STAT- MEDLINE
DCOM- 19960718
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 88
IP  - 2
DP  - 1996 Jun
TI  - No FISH evidence for trisomy 7 in normal or leukemic bone marrow.
PG  - 133-5
AB  - Trisomy 7 has been found as the sole chromosomal anomaly in both benign and 
      malignant tumors, as well as in nonneoplastic lesions. It has been reported that 
      +7 may occur in tumor-infiltrating as well as in peripheral T cell and in the 
      thymus. The precursor cells, which mature in the thymus to T lymphocytes, 
      originate in the bone marrow and the present study was undertaken to investigate 
      whether cells carrying an extra chromosome 7 can be detected there. Bone marrow 
      samples from five hematologically normal individuals and 12 children with acute 
      lymphoblastic leukemia (ALL) were analyzed by interphase fluorescence in situ 
      hybridization (FISH) using a chromosome 7 centromere-specific probe. Half of the 
      ALLs were karyotypically normal, whereas the other half displayed clonal 
      abnormalities (one pseudodiploid and five hyperdiploid karyotypes, none of which 
      had +7). The FISH analysis showed no evidence of cells with trisomy 7 in the bone 
      marrow samples from the controls or ALLs. This suggests that the gain of a 
      chromosome 7 by T lymphocytes does not occur before the bone marrow precursor 
      cells are conditioned in the thymus.
FAU - Kohler, M
AU  - Kohler M
AD  - Department of Clinical Genetics, University Hospital, Lund, Sweden.
FAU - Johansson, B
AU  - Johansson B
FAU - Garwicz, S
AU  - Garwicz S
FAU - Heim, S
AU  - Heim S
FAU - Mitelman, F
AU  - Mitelman F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Chromosomes, Human, Pair 7/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Trisomy/*genetics
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 0165-4608(95)00299-5 [pii]
AID - 10.1016/0165-4608(95)00299-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Jun;88(2):133-5. doi: 10.1016/0165-4608(95)00299-5.