PMID- 8642270
OWN - NLM
STAT- MEDLINE
DCOM- 19960716
LR  - 20211203
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 183
IP  - 3
DP  - 1996 Mar 1
TI  - An immunoglobulin E-dependent recombinant histamine-releasing factor induces 
      interleukin-4 secretion from human basophils.
PG  - 1265-70
AB  - A novel recombinant histamine-releasing factor (rHFR), which stimulates secretion 
      from a subpopulation of human basophils that express a particular type of 
      immunoglobulin E (IgE) or IgE+, was found to induce interleukin-4 (IL-4) 
      production from cells isolated from these same donors. The secretion of IL-4 
      protein induced by rHRF significantly correlated with histamine release and the 
      amount of protein generated, and the kinetics were identical to those caused by 
      anti-IgE activation. Furthermore, the ability of rHRF to induce IL-4 protein 
      production from cells not normally responsive to this protein was transferred by 
      passive sensitization with plasma containing IgE+ antibody. That this novel 
      protein stimulates both mediator release and the secretion of IL-4 protein from 
      human basophils suggests a prominent role for this molecule in allergic disease.
FAU - Schroeder, J T
AU  - Schroeder JT
AD  - The Johns Hopkins Asthma and Allergy Center, Department of Medicine, Baltimore, 
      Maryland 22124, USA.
FAU - Lichtenstein, L M
AU  - Lichtenstein LM
FAU - MacDonald, S M
AU  - MacDonald SM
LA  - eng
GR  - AI-07290/AI/NIAID NIH HHS/United States
GR  - AI-32561/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA, Complementary)
RN  - 0 (Interleukin-3)
RN  - 0 (Lymphokines)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Protein, Translationally-Controlled 1)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Basophils/drug effects/*immunology
MH  - *Biomarkers, Tumor
MH  - Cells, Cultured
MH  - Chemokine CCL2/pharmacology
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Histamine Release/drug effects
MH  - Humans
MH  - Immunization, Passive
MH  - Immunoglobulin E/*biosynthesis
MH  - Interleukin-3/pharmacology
MH  - Interleukin-4/*biosynthesis
MH  - Kinetics
MH  - *Lymphokines/*pharmacology
MH  - Recombinant Proteins/pharmacology
MH  - Tumor Protein, Translationally-Controlled 1
PMC - PMC2192336
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
PMCR- 1996/09/01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
PHST- 1996/09/01 00:00 [pmc-release]
AID - 96228349 [pii]
AID - 10.1084/jem.183.3.1265 [doi]
PST - ppublish
SO  - J Exp Med. 1996 Mar 1;183(3):1265-70. doi: 10.1084/jem.183.3.1265.