PMID- 8645111
OWN - NLM
STAT- MEDLINE
DCOM- 19960715
LR  - 20200324
IS  - 0304-8608 (Print)
IS  - 1432-8798 (Electronic)
IS  - 0304-8608 (Linking)
VI  - 141
IP  - 3-4
DP  - 1996
TI  - Kinetics of humoral immune response to the major structural proteins of the 
      porcine reproductive and respiratory syndrome virus.
PG  - 751-61
AB  - The kinetics of appearance of antibodies directed to the major structural 
      proteins N, M and E of porcine reproductive and respiratory syndrome virus 
      (PRRSV) was followed in pigs naturally- and experimentally-exposed to the virus. 
      Specific IgM antibody titers were first detected by indirect immunofluorescence 
      (IIF) at the end of the first week of PRRSV infection, peaked by day 14 to 21 
      post-inoculation (p.i.), then rapidly decreased to undetectable levels by day 35 
      to 42 p.i. On the other hand, specific IgG antibody titers peaked by day 21 to 28 
      p.i. and remained unchanged to the end of the 6- or 9-week observation period; in 
      addition, a persistent viremia was observed. Virus neutralizing (VN) antibody 
      titers > 8 were not detected until 3 to 4 weeks p.i. Taken together, the results 
      obtained by Western blotting analyses using purified virus and E. coli-expressed 
      ORFs 5 to 7 gene products, suggested that antibodies directed against the 
      envelope E protein appear by day 7 p.i., whereas antibodies directed against the 
      nucleocapsid N and membrane M proteins can only be detected by the end of the 
      second week p.i. No correlation could be demonstrated between VN and IIF antibody 
      titers, viremia, and viral protein specificities of circulating antibodies at 
      various times p.i.
FAU - Loemba, H D
AU  - Loemba HD
AD  - Centre de Recherche en Virologie, Institut Armand-Frappier, Universite du Quebec, 
      Laval, Canada.
FAU - Mounir, S
AU  - Mounir S
FAU - Mardassi, H
AU  - Mardassi H
FAU - Archambault, D
AU  - Archambault D
FAU - Dea, S
AU  - Dea S
LA  - eng
SI  - GENBANK/L40898
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Viral Structural Proteins)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/*biosynthesis/immunology
MH  - Antibody Formation
MH  - Arterivirus/*immunology
MH  - Arterivirus Infections/*immunology/pathology/virology
MH  - Blotting, Western
MH  - Cell Line
MH  - Immunoglobulin G/biosynthesis/immunology
MH  - Immunoglobulin M/biosynthesis/immunology
MH  - Kinetics
MH  - Molecular Sequence Data
MH  - Swine
MH  - Swine Diseases/*immunology/pathology/virology
MH  - Viral Structural Proteins/*immunology
PMC - PMC7086943
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
PMCR- 2020/03/23
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PHST- 2020/03/23 00:00 [pmc-release]
AID - BF01718333 [pii]
AID - 10.1007/BF01718333 [doi]
PST - ppublish
SO  - Arch Virol. 1996;141(3-4):751-61. doi: 10.1007/BF01718333.