PMID- 8645791
OWN - NLM
STAT- MEDLINE
DCOM- 19960725
LR  - 20190512
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 21
IP  - 4
DP  - 1995 Oct
TI  - Direct sequence analysis of human herpesvirus 6 (HHV-6) sequences from infants 
      and comparison of HHV-6 sequences from mother/infant pairs.
PG  - 1017-9
AB  - Direct sequence analysis of polymerase chain reaction-amplified DNA fragments 
      from the large tegument protein (LTP) gene of human herpesvirus 6 (HHV-6) was 
      performed with use of uncultured peripheral blood mononuclear cells (PBMCs) from 
      four mother/infant pairs. In two cases, LTP gene sequences were identical in 
      paired mother/infant specimens, thus suggesting that mother-to-infant 
      transmission of HHV-6 may have occurred. The genetic stability of HHV-6 strains 
      was confirmed by the fact that there was no difference between amplified DNA 
      fragments from sequential PBMC samples from two of two infants analyzed. In 
      contrast, a change in the amplified viral strain was detected in an infant who 
      had reinfection with HHV-6 variant B (HHV-6B). Furthermore, HHV-6B strains 
      concurrently amplified from saliva and PBMCs from an adult were found to be 
      different. The data suggest that HHV-6 may be frequently transmitted from 
      mother-to-infant and that reinfection with HHV-6B may occur.
FAU - van Loon, N M
AU  - van Loon NM
AD  - Department of Microbiology and Immunology, University of Rochester Medical 
      Center, New York 14642, USA.
FAU - Gummuluru, S
AU  - Gummuluru S
FAU - Sherwood, D J
AU  - Sherwood DJ
FAU - Marentes, R
AU  - Marentes R
FAU - Hall, C B
AU  - Hall CB
FAU - Dewhurst, S
AU  - Dewhurst S
LA  - eng
SI  - GENBANK/U19587
SI  - GENBANK/U19588
SI  - GENBANK/U19589
SI  - GENBANK/U19590
GR  - KO4 AI01240/AI/NIAID NIH HHS/United States
GR  - R01 A133020/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (DNA, Viral)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Adult
MH  - Base Sequence
MH  - Child, Preschool
MH  - DNA, Viral/*genetics
MH  - Female
MH  - Herpesviridae Infections/transmission/virology
MH  - Herpesvirus 6, Human/*genetics/isolation & purification
MH  - Humans
MH  - Infant
MH  - Infectious Disease Transmission, Vertical
MH  - Leukocytes, Mononuclear/virology
MH  - Molecular Sequence Data
MH  - Saliva/virology
MH  - Sequence Analysis, DNA
MH  - Viral Proteins/genetics
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1093/clinids/21.4.1017 [doi]
PST - ppublish
SO  - Clin Infect Dis. 1995 Oct;21(4):1017-9. doi: 10.1093/clinids/21.4.1017.