PMID- 8646734
OWN - NLM
STAT- MEDLINE
DCOM- 19960725
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 87
IP  - 1
DP  - 1996 Mar
TI  - Cytogenetic characterization of the human prostate cancer cell line P69SV40T and 
      its novel tumorigenic sublines M2182 and M15.
PG  - 14-23
AB  - Cytogenetic studies of a SV40T antigen immortalized human prostate epithelial 
      cell line (P69SV40T) and its increasingly tumorigenic tumor sublines, designated 
      M2182 and M15, were done with GTG-banding and multicolor fluorescence in situ 
      hybridization (FISH). The parental line and each of the two sublines were 
      near-diploid and contained several consistent abnormalities. Two structural 
      chromosome anomalies were noted in all three lines; a der(7)t(5;20;7) and a 
      der(5)t(5;9). Abnormalities that were acquired and retained in the tumor sublines 
      after in vivo and/or in vitro selection included a der(1)t(1;8), der(3)t(3;14), 
      der(20)t(7;20), and der(X)t(X;11). Findings unique to subline M2182 were a 
      der(11)t(5;11) and -14. Those unique to M15 were a der(16)t(16;19) and -Y. 
      Chromosome imbalances resulting from numerical and/or structural abnormalities in 
      the tumor sublines involved several chromosome regions that have previously been 
      implicated in human prostate cancer, such as loss of Xp, Y, 3p (M2182 and M15), 
      16q (M15), and gains for 5q (M2182) and 8q (M2182 and M15). Collectively, the 
      characterization of these lines should assist with the localization of chromosome 
      regions, and possibly genes, that are important in the development and 
      progression of human prostate cancer.
FAU - Jackson-Cook, C
AU  - Jackson-Cook C
AD  - Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth 
      University, Richmond, VA 23298-0033, USA.
FAU - Bae, V
AU  - Bae V
FAU - Edelman, W
AU  - Edelman W
FAU - Brothman, A
AU  - Brothman A
FAU - Ware, J
AU  - Ware J
LA  - eng
GR  - R01 DK052683/DK/NIDDK NIH HHS/United States
GR  - R01-CA46269/CA/NCI NIH HHS/United States
GR  - R01CA58126/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Animals
MH  - *Chromosome Aberrations
MH  - ErbB Receptors/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mice
MH  - Mice, Nude
MH  - Prostatic Neoplasms/*genetics
MH  - Tumor Cells, Cultured
MH  - Y Chromosome
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 0165460895002324 [pii]
AID - 10.1016/0165-4608(95)00232-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Mar;87(1):14-23. doi: 10.1016/0165-4608(95)00232-4.