PMID- 8646739
OWN - NLM
STAT- MEDLINE
DCOM- 19960725
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 87
IP  - 1
DP  - 1996 Mar
TI  - t(1;5)(q23;q33) in a patient with high-risk B-lineage acute lymphoblastic 
      leukemia.
PG  - 4-6
AB  - The t(1;5)(q23;q33) is a rare genetic anomaly that was reported previously in two 
      infants with a myeloproliferative disorder and eosinophilia and in one adult 
      patient with acute nonlymphocytic leukemia (ANLL). A 13-year-old boy with 
      high-risk early pre-B acute lymphoblastic leukemia (ALL) who presented to our 
      institution carried the t(1;5)(q23;q33). He had an initial blast count of 230 X 
      10(9)/L and responded poorly to prednisone. Complete remission (CR) was achieved, 
      and he had a bone marrow (BM) relapse 3 months after despite intensive 
      consolidation therapy. He underwent allogeneic BM transplantation (BMT) from a 
      human leukocyte antigen (HLA)-identical siblings in early relapse with total body 
      irradiation (TBI) and cyclophosphamide conditioning. He had a short second CR 
      with a central nervous system (CNS) relapse on day + 106 after BMT. Two of the 
      previously reported patients also did not respond to chemotherapy. The 
      t(1;5)(q23;q33) appears to be a rare lineage nonspecific anomaly related to 
      hematologic malignancies that are resistant to current therapy.
FAU - Barriga, F
AU  - Barriga F
AD  - Department of Pediatrics, Universidad Catolica, Santiago, Chile.
FAU - Bertin, P
AU  - Bertin P
FAU - Legues, E
AU  - Legues E
FAU - Risueno, C
AU  - Risueno C
FAU - Andrade, W
AU  - Andrade W
FAU - Cabrera, E
AU  - Cabrera E
FAU - Grebe, G
AU  - Grebe G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 5
MH  - Humans
MH  - Male
MH  - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Translocation, Genetic
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 0165460895002170 [pii]
AID - 10.1016/0165-4608(95)00217-0 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Mar;87(1):4-6. doi: 10.1016/0165-4608(95)00217-0.