PMID- 8646740
OWN - NLM
STAT- MEDLINE
DCOM- 19960725
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 87
IP  - 1
DP  - 1996 Mar
TI  - Chromosome breakpoint at 17q11.2 and insertion of DNA from three different 
      chromosomes in a glioblastoma with exceptional glial fibrillary acidic protein 
      expression.
PG  - 41-7
AB  - A glioblastoma that retained glial fibrillary acidic protein (GFAP) in culture 
      has a break in the long arm of chromosome 17 at band 17q11.2. DNA inserted at 
      this breakpoint came from chromosome bands 3p21, 3q23, 16q11.2, and 22q11.2. 
      These chromosome fragments were inserted in band 17q11.2 proximal to the 
      neurofibromatosis-1 (NF-1) gene and neu (HER2; erbB2) oncogene loci. The 
      glioblastoma also contained a reciprocal translocation between 16p12 and 20p12. 
      These structural abnormalities, previously undescribed in gliomas, were 
      demonstrated by high-resolution chromosome banding, microdissection, and 
      fluorescence in situ hybridization (FISH). Numerical changes typical of 
      glioblastoma were present: gain of chromosome 7 and losses of chromosomes 10, 13, 
      and 22. The complex chromosome origin of DNA inserted in this glioma chromosome 
      is described. The association of two infrequent events in this single 
      glioblastoma line, this complex insertion and retention of GFAP expression, is 
      not likely to be a chance occurrence. It raises the possibility of an association 
      between the two events.
FAU - McKeever, P E
AU  - McKeever PE
AD  - Department of Pathology, University of Michigan Medical School, Ann Arbor 
      48109-0602, USA.
FAU - Dennis, T R
AU  - Dennis TR
FAU - Burgess, A C
AU  - Burgess AC
FAU - Meltzer, P S
AU  - Meltzer PS
FAU - Marchuk, D A
AU  - Marchuk DA
FAU - Trent, J M
AU  - Trent JM
LA  - eng
GR  - CA47558/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Glial Fibrillary Acidic Protein)
SB  - IM
MH  - Cells, Cultured
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 16
MH  - *Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 22
MH  - Chromosomes, Human, Pair 3
MH  - Glial Fibrillary Acidic Protein/*analysis
MH  - Glioblastoma/chemistry/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 0165460895002375 [pii]
AID - 10.1016/0165-4608(95)00237-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1996 Mar;87(1):41-7. doi: 10.1016/0165-4608(95)00237-5.