PMID- 8649516
OWN - NLM
STAT- MEDLINE
DCOM- 19960725
LR  - 20061115
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 381
IP  - 6584
DP  - 1996 Jun 20
TI  - RAPID and opposite effects of BDNF and NGF on the functional organization of the 
      adult cortex in vivo.
PG  - 702-6
AB  - The adult cortex is thought to undergo plastic changes that are closely dependent 
      on neuronal activity (reviewed in ref. 1), although it is not yet known what 
      molecules are involved. Neurotrophins and their receptors have been implicated in 
      several aspects of developmental plasticity, and their expression in the adult 
      cortex suggests additional roles in adult plasticity. To examine these potential 
      roles in vivo, we used intrinsic-signal optical imaging to quantify the effects 
      of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) on the 
      functional representation of a stimulated whisker in the 'barrel' subdivision of 
      the rat somatosensory cortex. Topical application of BDNF resulted in a rapid and 
      long-lasting decrease in the size of a whisker representation, and a decrease in 
      the amplitude of the activity-dependent intrinsic signal. In contrast, NGF 
      application resulted in a rapid but transient increase in the size of a 
      representation, and an increase in the amplitude of the activity-dependent 
      intrinsic signal. These results demonstrate that neurotrophins can rapidly 
      modulate stimulus-dependent activity in adult cortex, and suggest a role for 
      neurotrophins in regulating adult cortical plasticity.
FAU - Prakash, N
AU  - Prakash N
AD  - Department of Psychobiology and the Center for Learning and Memory, University of 
      California at Irvine, 92717, USA.
FAU - Cohen-Cory, S
AU  - Cohen-Cory S
FAU - Frostig, R D
AU  - Frostig RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Diagnostic Imaging
MH  - Male
MH  - Nerve Growth Factors/*physiology
MH  - Nerve Tissue Proteins/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptors, Nerve Growth Factor/metabolism
MH  - Somatosensory Cortex/*physiology
MH  - Time Factors
MH  - Vibrissae/physiology
EDAT- 1996/06/20 00:00
MHDA- 1996/06/20 00:01
CRDT- 1996/06/20 00:00
PHST- 1996/06/20 00:00 [pubmed]
PHST- 1996/06/20 00:01 [medline]
PHST- 1996/06/20 00:00 [entrez]
AID - 10.1038/381702a0 [doi]
PST - ppublish
SO  - Nature. 1996 Jun 20;381(6584):702-6. doi: 10.1038/381702a0.