PMID- 8649517
OWN - NLM
STAT- MEDLINE
DCOM- 19960725
LR  - 20220309
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 381
IP  - 6584
DP  - 1996 Jun 20
TI  - Regulation of synaptic responses to high-frequency stimulation and LTP by 
      neurotrophins in the hippocampus.
PG  - 706-9
AB  - Neurotrophins promote neuronal survival and differentiation, but the fact that 
      their expression is modified by neuronal activity, suggests a role in regulating 
      synapse development and plasticity. In developing hippocampus, the expression of 
      brain derived neurotrophic factor (BDNF) and its receptor TrkB increases in 
      parallel with the ability to undergo long-term potentiation (LTP). Here we report 
      a mechanism by which BDNF modulates hippocampal LTP. Exogenous BDNF promoted the 
      induction of LTP by tetanic stimulation in young (postnatal day 12-13) 
      hippocampal slices, which in the absence of BDNF show only short-term 
      potentiation (STP). This effect was due to an enhanced ability of hippocampal 
      synapses to respond to tetanic stimulation, rather than to a direct modulation of 
      the LTP-triggering mechanism. A TrkB-IgG fusion protein, which scavenges 
      endogenous BDNF, reduced the synaptic responses to tetanus as well as the 
      magnitude of LTP in adult hippocampus. Our results suggest that BDNF may regulate 
      LTP in developing and adult hippocampus by enhancing synaptic responses to 
      tetanic stimulation.
FAU - Figurov, A
AU  - Figurov A
AD  - Roche Institue of Molecular Biology, Nutley, New Jersey 07110, USA.
FAU - Pozzo-Miller, L D
AU  - Pozzo-Miller LD
FAU - Olafsson, P
AU  - Olafsson P
FAU - Wang, T
AU  - Wang T
FAU - Lu, B
AU  - Lu B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Evoked Potentials
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Immunoglobulin G/immunology
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Nerve Growth Factors/antagonists & inhibitors/*physiology
MH  - Nerve Tissue Proteins/antagonists & inhibitors/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptors, Nerve Growth Factor/physiology
MH  - Recombinant Proteins/pharmacology
MH  - Synapses/*physiology
EDAT- 1996/06/20 00:00
MHDA- 1996/06/20 00:01
CRDT- 1996/06/20 00:00
PHST- 1996/06/20 00:00 [pubmed]
PHST- 1996/06/20 00:01 [medline]
PHST- 1996/06/20 00:00 [entrez]
AID - 10.1038/381706a0 [doi]
PST - ppublish
SO  - Nature. 1996 Jun 20;381(6584):706-9. doi: 10.1038/381706a0.