PMID- 8650584
OWN - NLM
STAT- MEDLINE
DCOM- 19960725
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 272
IP  - 5269
DP  - 1996 Jun 21
TI  - Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus.
PG  - 1811-3
AB  - Insulin-dependent diabetes mellitus (IDDM) is a multigenic autoimmune disease. An 
      IDDM susceptibility gene was mapped to chromosome 2q34. This gene may act early 
      in diabetogenesis, because "preclinical" individuals also showed linkage. Human 
      leukocyte antigen (HLA)-disparate, but not HLA-identical, sibs showed linkage, 
      which was even stronger in families with affected females. The genes encoding 
      insulin-like growth factor-binding proteins 2 and 5 were mapped to a 4-megabase 
      pair interval near this locus. These results indicate the existence of a gene 
      that acts at an early stage in IDDM development, screening for which may identify 
      a specific subset of at-risk individuals.
FAU - Morahan, G
AU  - Morahan G
AD  - Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, 
      Victoria, Australia. morahan@wehi.edu.au
FAU - Huang, D
AU  - Huang D
FAU - Tait, B D
AU  - Tait BD
FAU - Colman, P G
AU  - Colman PG
FAU - Harrison, L C
AU  - Harrison LC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Autoantibodies)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 2)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 5)
RN  - 0 (islet cell antibody)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Autoantibodies/analysis
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 2/*genetics
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Linkage
MH  - *Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 2/genetics
MH  - Insulin-Like Growth Factor Binding Protein 5/genetics
MH  - Islets of Langerhans/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred NOD/genetics
MH  - Microsatellite Repeats
EDAT- 1996/06/21 00:00
MHDA- 1996/06/21 00:01
CRDT- 1996/06/21 00:00
PHST- 1996/06/21 00:00 [pubmed]
PHST- 1996/06/21 00:01 [medline]
PHST- 1996/06/21 00:00 [entrez]
AID - 10.1126/science.272.5269.1811 [doi]
PST - ppublish
SO  - Science. 1996 Jun 21;272(5269):1811-3. doi: 10.1126/science.272.5269.1811.