PMID- 8653380
OWN - NLM
STAT- MEDLINE
DCOM- 19960730
LR  - 20190905
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 32
IP  - 12
DP  - 1996 Jun
TI  - Temporal induction pattern of hepatic cytochrome P450 1A in thermally acclimated 
      dab (Limanda limanda) treated with 3,3',4,4'-tetrachlorobiphenyl (CB77).
PG  - 2335-44
AB  - Mature male dab (Limanda limanda) acclimated at 10 degrees and 16 degrees C were 
      orally administered a single dose of 0.5 mg/kg 3,3',4,4'-tetrachlorobiphenyl 
      (CB77). At both temperatures, levels of cytochrome P450 1A (CYP1A) protein and 
      7-ethoxyresorufin O-deethylase (EROD) activity showed a two to six fold induction 
      40 days after CB77 treatment compared to control groups. Maximum responses of 
      both EROD activity and CYP1A protein for the warm-acclimated fish were observed 
      at 5 days after treatment. For the cold-acclimated fish a slow, progressive 
      elevation for both EROD activity and CYP1A protein was observed and maximum 
      responses were measured 40 days after treatment. Absolute EROD activity and CYP1A 
      protein levels of fish from both temperatures were equally high at 40 days after 
      treatment. Since in the control groups EROD activity and CYP1A protein levels 
      were higher in the cold-acclimated fish, the magnitude of induction was higher in 
      the warm acclimated ones. The highest concentrations of CB77 in muscle of fish 
      from both temperatures were found at 5 and 10 days after treatment. The liver 
      somatic index (LSI) showed 1.5 fold significantly higher values for the fish 
      acclimated at 10 degrees C.
FAU - Sleiderink, H M
AU  - Sleiderink HM
AD  - Netherlands Institute for Sea Research, Den Burg, The Netherlands.
FAU - Boon, J P
AU  - Boon JP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - Y2I6546TMI (3,4,3',4'-tetrachlorobiphenyl)
SB  - IM
MH  - Administration, Oral
MH  - Analysis of Variance
MH  - Animals
MH  - Cytochrome P-450 CYP1A1
MH  - Cytochrome P-450 Enzyme System/*biosynthesis
MH  - Enzyme Induction/drug effects
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Flounder
MH  - Linear Models
MH  - Liver/*enzymology
MH  - Male
MH  - Muscles/metabolism
MH  - Oxidoreductases/*biosynthesis
MH  - Polychlorinated Biphenyls/administration & dosage/pharmacokinetics/*toxicity
MH  - Temperature
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 0045653596001373 [pii]
AID - 10.1016/0045-6535(96)00137-3 [doi]
PST - ppublish
SO  - Chemosphere. 1996 Jun;32(12):2335-44. doi: 10.1016/0045-6535(96)00137-3.