PMID- 8653826
OWN - NLM
STAT- MEDLINE
DCOM- 19960801
LR  - 20190623
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 93
IP  - 6
DP  - 1996 Mar 15
TI  - Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize 
      to chromosomes 11q13 and 4q34, respectively.
PG  - 1079-82
AB  - BACKGROUND: Vascular endothelial growth factor (VEGF) is an important regulator 
      of endothelial cell proliferation, migration, and permeability during embryonic 
      vasculogenesis as well as in physiological and pathological angiogenesis. The 
      recently isolated VEGF-B and VEGF-C cDNAs encode novel growth factor genes of the 
      VEGF family. METHODS AND RESULTS: Southern blotting and polymerase chain reaction 
      analysis of somatic cell hybrids and fluorescence in situ hybridization (FISH) of 
      metaphase chromosomes were used to assess the chromosomal localization of VEGF-B 
      and VEGF-C genes. The VEGF-B gene was found on chromosome 11q13, proximal to the 
      cyclin D1 gene, which is amplified in a number of human carcinomas. However, 
      VEGF-B was not amplified in several mammary carcinoma cell lines containing 
      amplified cyclin D1. The VEGF-C gene was located on chromosome 4q34, close to the 
      human aspartylglucosaminidase gene previously mapped to 4q34-35. CONCLUSIONS: The 
      VEGF-B locus in 11q13 and the VEGF-C locus in 4q34 are candidate targets for 
      mutations that lead to vascular malformations or cardiovascular diseases.
FAU - Paavonen, K
AU  - Paavonen K
AD  - Molecular/Cancer Biology Laboratory, Haartman Institute, Helsinki, Finland.
FAU - Horelli-Kuitunen, N
AU  - Horelli-Kuitunen N
FAU - Chilov, D
AU  - Chilov D
FAU - Kukk, E
AU  - Kukk E
FAU - Pennanen, S
AU  - Pennanen S
FAU - Kallioniemi, O P
AU  - Kallioniemi OP
FAU - Pajusola, K
AU  - Pajusola K
FAU - Olofsson, B
AU  - Olofsson B
FAU - Eriksson, U
AU  - Eriksson U
FAU - Joukov, V
AU  - Joukov V
FAU - Palotie, A
AU  - Palotie A
FAU - Alitalo, K
AU  - Alitalo K
LA  - eng
SI  - GENBANK/U48800
SI  - GENBANK/X94216
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Lymphokines)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
SB  - IM
MH  - Base Sequence
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 4
MH  - Endothelial Growth Factors/*genetics
MH  - Humans
MH  - Lymphokines/*genetics
MH  - Molecular Sequence Data
MH  - Tumor Cells, Cultured
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
EDAT- 1996/03/15 00:00
MHDA- 1996/03/15 00:01
CRDT- 1996/03/15 00:00
PHST- 1996/03/15 00:00 [pubmed]
PHST- 1996/03/15 00:01 [medline]
PHST- 1996/03/15 00:00 [entrez]
AID - 10.1161/01.cir.93.6.1079 [doi]
PST - ppublish
SO  - Circulation. 1996 Mar 15;93(6):1079-82. doi: 10.1161/01.cir.93.6.1079.