PMID- 8654417
OWN - NLM
STAT- MEDLINE
DCOM- 19960730
LR  - 20190620
IS  - 0014-2956 (Print)
IS  - 0014-2956 (Linking)
VI  - 235
IP  - 3
DP  - 1996 Feb 1
TI  - Regulation of glutamate dehydrogenase expression in the developing rat liver: 
      control at different levels in the prenatal period.
PG  - 677-82
AB  - To study the regulation of the expression of glutamate dehydrogenase (Glu-DH) in 
      rat liver during development, the Glu-DH mRNA concentration in the liver of rats 
      ranging in age from 14 days prenatal development to 3 months after birth was 
      determined. This concentration increased up to two days before birth, decreased 
      rapidly between two days before and one day after birth and increased again in 
      the second and third postnatal week. The ratio of Glu-DH mRNA/protein decreased 
      more than 10-fold in the prenatal period, whereas it did not change significantly 
      after birth. Thus, whereas the ratio between the Glu-DH monomer protein molecules 
      and Glu-DH mRNA molecules is found to be approximately 1400 at 14 days of 
      prenatal development, it is approximately 1700 four weeks after birth. We argue 
      than an increase in the translational efficiency after birth is the most likely 
      cause of the observed developmental changes in Glu-DH mRNA/protein ratio. Our 
      results suggest that the expression after birth is predominantly regulated at the 
      pretranslational level, whereas the prenatal Glu-DH expression is regulated both 
      at the translational level and at the pretranslational level.
FAU - Das, A T
AU  - Das AT
AD  - Department of Anatomy and Embryology, University of Amsterdam, Academic Medical 
      Center, The Netherlands.
FAU - Salvado, J
AU  - Salvado J
FAU - Boon, L
AU  - Boon L
FAU - Biharie, G
AU  - Biharie G
FAU - Moorman, A F
AU  - Moorman AF
FAU - Lamers, W H
AU  - Lamers WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Biochem
JT  - European journal of biochemistry
JID - 0107600
RN  - 0 (RNA, Messenger)
RN  - EC 1.4.1.2 (Glutamate Dehydrogenase)
SB  - IM
MH  - Animals
MH  - *Gene Expression Regulation, Developmental
MH  - *Gene Expression Regulation, Enzymologic
MH  - Glutamate Dehydrogenase/*genetics/metabolism
MH  - Liver/embryology/*enzymology/growth & development
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Wistar
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 10.1111/j.1432-1033.1996.00677.x [doi]
PST - ppublish
SO  - Eur J Biochem. 1996 Feb 1;235(3):677-82. doi: 10.1111/j.1432-1033.1996.00677.x.