PMID- 8655325
OWN - NLM
STAT- MEDLINE
DCOM- 19960730
LR  - 20190722
IS  - 0017-9078 (Print)
IS  - 0017-9078 (Linking)
VI  - 71
IP  - 1
DP  - 1996 Jul
TI  - The results of selective cytogenetic monitoring of Chernobyl accident victims in 
      the Ukraine.
PG  - 29-33
AB  - Selective cytogenetic monitoring of the highest priority groups of Chernobyl 
      disaster victims has been carried out since 1987. In 1992-1993, 125 liquidators 
      (irradiated mainly in 1986) and 42 persons recovering from acute radiation 
      sickness of the second and third degrees of severity were examined. Cytogenetic 
      effects (an elevated level of unstable as well as stable markers of radiation 
      exposure) were found in all groups, which showed a positive correlation with the 
      initial degree of irradiation severity even 6-7 y after the accident. Comparative 
      scoring of conventional staining vs. G-banding in 10 liquidators showed the 
      identical rate of unstable aberrations. At the same time, the yield of stable 
      aberrations for G-banded slides exceeded the frequency for conventional staining. 
      In order to study possible mutagenic activity of chronic low levels of 
      irradiation, the cytogenetic monitoring of some critical groups of the population 
      (especially children and occupational groups--tractor drivers and foresters) 
      living in areas of the Ukraine contaminated by radionuclides was carried out. In 
      all the examined groups, a significant increase in the frequency of aberrant 
      metaphases, chromosome aberrations (both unstable and stable), and chromatid 
      aberrations was observed. Data gathered from groups of children reflect the 
      intensity of mutagenic impact on the studied populations and demonstrate a 
      positive correlation with the duration of exposure. Results of cytogenetic 
      examination of adults confirmed the importance of considering the contribution of 
      occupational radiation exposure to genetic effects of Chernobyl accident factors 
      on the population of contaminated areas. Results of our investigations 
      demonstrated the possibility of evaluating the mutagenic impact of acute and 
      long-term irradiation of different intensities on somatic cells of persons 
      undergoing radiation exposure due to the Chernobyl accident and confirmed the 
      need to introduce new informative genetic methods [especially fluorescence in 
      situ hybridization (FISH)] for reliable retrospective cytogenetic dosimetry of 
      radiation exposure in Chernobyl accident victims.
FAU - Pilinskaya, M A
AU  - Pilinskaya MA
AD  - Research Center of Radiation Medicine, Kiev, Ukraine.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Phys
JT  - Health physics
JID - 2985093R
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Humans
MH  - Nuclear Reactors
MH  - *Power Plants
MH  - *Radioactive Hazard Release
MH  - Ukraine
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1097/00004032-199607000-00004 [doi]
PST - ppublish
SO  - Health Phys. 1996 Jul;71(1):29-33. doi: 10.1097/00004032-199607000-00004.