PMID- 8656014
OWN - NLM
STAT- MEDLINE
DCOM- 19960731
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 174
IP  - 1
DP  - 1996 Jul
TI  - Inhibition of immunoreactive tumor necrosis factor-alpha by a chimeric antibody 
      in patients infected with human immunodeficiency virus type 1.
PG  - 63-8
AB  - Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine known to 
      stimulate human immunodeficiency virus type 1 (HIV-1) replication, has been 
      implicated in the pathogenesis of HIV-1 infection. Inhibition of TNF-alpha by a 
      chimeric humanized monoclonal antibody, cA2, was investigated in 6 HIV-1-infected 
      patients with CD4 cell counts < 200/mm3. Two consecutive infusions of 10 mg/kg 14 
      days apart were well tolerated, and a prolonged serum half-life for cA2 (mean, 
      257 +/- 70 h) was demonstrated. Serum immunoreactive TNF-alpha concentrations 
      fell from a mean prestudy value of 6.4 pg/mL (range, 4.2-7.9) to 1.1 pg/mL 
      (range, 0.5-2.2) 24 h after the first infusion and returned to baseline within 
      7-14 days. A similar response was seen after the second infusion. No consistent 
      changes in CD4 cell counts or plasma HIV RNA levels were observed over 42 days. 
      Future studies evaluating the therapeutic utility of long-term TNF-alpha 
      suppression using anti-TNF-alpha antibodies are feasible and warranted.
FAU - Walker, R E
AU  - Walker RE
AD  - National Institute of Allergy and Infectious Diseases, Critical Care Medicine 
      Department, National Institutes of Health, Bethesda, MD 20892, USA.
FAU - Spooner, K M
AU  - Spooner KM
FAU - Kelly, G
AU  - Kelly G
FAU - McCloskey, R V
AU  - McCloskey RV
FAU - Woody, J N
AU  - Woody JN
FAU - Falloon, J
AU  - Falloon J
FAU - Baseler, M
AU  - Baseler M
FAU - Piscitelli, S C
AU  - Piscitelli SC
FAU - Davey, R T Jr
AU  - Davey RT Jr
FAU - Polis, M A
AU  - Polis MA
FAU - Kovacs, J A
AU  - Kovacs JA
FAU - Masur, H
AU  - Masur H
FAU - Lane, H C
AU  - Lane HC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/blood/*immunology
MH  - Adult
MH  - Animals
MH  - Antibodies/*therapeutic use
MH  - Antibodies, Monoclonal/*therapeutic use
MH  - Female
MH  - *HIV-1
MH  - Humans
MH  - Male
MH  - Mice
MH  - Recombinant Fusion Proteins/pharmacokinetics/*therapeutic use
MH  - Recombinant Proteins/pharmacokinetics/therapeutic use
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors/immunology
EDAT- 1996/07/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1093/infdis/174.1.63 [doi]
PST - ppublish
SO  - J Infect Dis. 1996 Jul;174(1):63-8. doi: 10.1093/infdis/174.1.63.