PMID- 8656282
OWN - NLM
STAT- MEDLINE
DCOM- 19960730
LR  - 20220310
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 16
IP  - 12
DP  - 1996 Jun 15
TI  - Brain-derived neurotrophic factor and neurotrophin-4/5 stimulate growth of axonal 
      branches from regenerating retinal ganglion cells.
PG  - 3887-94
AB  - To investigate the influences of growth factors on axonal regeneration in the 
      mammalian CNS, we used intracellular tracers to quantitate the effects of 
      brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-4/5, or NT-3 on 
      individual retinal ganglion cell (RGC) axons in the retinas of adult rats after 
      optic nerve transection. A single injection of BDNF or the prolonged 
      administration of NT-4/5 by mini-pump increased axon branch median lengths by 
      eightfold but had no effect on the number of branches formed by the RGC axons. 
      NT-3 did not significantly influence axonal regrowth. These specific in vivo 
      effects of BDNF and NT-4/5 on axonal regeneration from injured RGCs may be used 
      to promote growth and expand the abnormally small terminal arbors observed when 
      RGCs regrow into their CNS targets.
FAU - Sawai, H
AU  - Sawai H
AD  - Centre for Research in Neuroscience, Montreal General Hospital Research 
      Institute, Quebec, Canada.
FAU - Clarke, D B
AU  - Clarke DB
FAU - Kittlerova, P
AU  - Kittlerova P
FAU - Bray, G M
AU  - Bray GM
FAU - Aguayo, A J
AU  - Aguayo AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (neurobiotin)
RN  - 145172-44-7 (neurotrophin 5)
RN  - 6SO6U10H04 (Biotin)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Axons/drug effects/*physiology
MH  - Biotin/analogs & derivatives
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Division/drug effects
MH  - Cell Size/drug effects
MH  - Female
MH  - Nerve Growth Factors/*pharmacology
MH  - Nerve Regeneration/*drug effects
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Neurotrophin 3
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Retina/cytology
MH  - Retinal Ganglion Cells/cytology/physiology/*ultrastructure
MH  - Superior Colliculi/cytology
MH  - Time Factors
MH  - Visual Pathways
PMC - PMC6578616
EDAT- 1996/06/15 00:00
MHDA- 1996/06/15 00:01
PMCR- 1996/12/15
CRDT- 1996/06/15 00:00
PHST- 1996/06/15 00:00 [pubmed]
PHST- 1996/06/15 00:01 [medline]
PHST- 1996/06/15 00:00 [entrez]
PHST- 1996/12/15 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.16-12-03887.1996 [doi]
PST - ppublish
SO  - J Neurosci. 1996 Jun 15;16(12):3887-94. doi: 10.1523/JNEUROSCI.16-12-03887.1996.