PMID- 8661015
OWN - NLM
STAT- MEDLINE
DCOM- 19960920
LR  - 20111117
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 33
IP  - 3
DP  - 1996 May 1
TI  - Chromosomal mapping of the human M6 genes.
PG  - 532-6
AB  - M6 is a neuronal membrane glycoprotein that may have an important role in neural 
      development. This molecule was initially defined by a monoclonal antibody that 
      affected the survival of cultured cerebellar neurons and the outgrowth of 
      neurites. The nature of the antigen was discovered by expression cDNA cloning 
      using this monoclonal antibody. Two distinct murine M6 cDNAs (designated M6a and 
      M6b) whose deduced amino acid sequences were remarkably similar to that of the 
      myelin proteolipid protein were previously isolated. We have isolated partial 
      human cDNA and genomic clones encoding M6a and M6b and have characterized them by 
      restriction mapping, Southern hybridization with cDNA probes, and sequence 
      analysis. We have localized these genes within the human genome by FISH 
      (fluorescence in situ hybridization). The human M6a gene is located at 4q34, and 
      the M6b gene is located at Xp22.2. A number of human neurological disorders have 
      been mapped to the Xp22 region, including Aicardi syndrome (MIM 304050), Rett 
      syndrome (MIM 312750), X-linked Charcot-Marie-Tooth neuropathy (MIM 302801), and 
      X-linked mental retardation syndromes (MRX1, MIM 309530). This raises the 
      possibility that a defect in the M6b gene is responsible for one of these 
      neurological disorders.
FAU - Olinsky, S
AU  - Olinsky S
AD  - The Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, 
      Pennsylvania, 15213, USA.
FAU - Loop, B T
AU  - Loop BT
FAU - DeKosky, A
AU  - DeKosky A
FAU - Ripepi, B
AU  - Ripepi B
FAU - Weng, W
AU  - Weng W
FAU - Cummins, J
AU  - Cummins J
FAU - Wenger, S L
AU  - Wenger SL
FAU - Yan, Y
AU  - Yan Y
FAU - Lagenaur, C
AU  - Lagenaur C
FAU - Narayanan, V
AU  - Narayanan V
LA  - eng
SI  - GENBANK/U45955
SI  - GENBANK/U45956
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (DNA, Complementary)
RN  - 0 (GPM6A protein, human)
RN  - 0 (GPM6B protein, human)
RN  - 0 (Gpm6a protein, mouse)
RN  - 0 (Gpm6b protein, mouse)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Biological Evolution
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 4
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Genomic Library
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Intellectual Disability/genetics
MH  - Membrane Glycoproteins/biosynthesis/chemistry/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/biosynthesis/chemistry/*genetics
MH  - Nervous System Diseases/genetics
MH  - Neurons/*physiology
MH  - Restriction Mapping
MH  - Sequence Homology, Amino Acid
MH  - *X Chromosome
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - S0888-7543(96)90231-1 [pii]
AID - 10.1006/geno.1996.0231 [doi]
PST - ppublish
SO  - Genomics. 1996 May 1;33(3):532-6. doi: 10.1006/geno.1996.0231.