PMID- 8665972
OWN - NLM
STAT- MEDLINE
DCOM- 19960805
LR  - 20220409
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 16
IP  - 8
DP  - 1995 Aug
TI  - Sympathetic predominance followed by functional denervation in the progression of 
      chronic heart failure.
PG  - 1100-7
AB  - Using spectral analysis of heart rate and systolic arterial pressure 
      variabilities, the study was set up to evaluate cardiovascular efferent autonomic 
      modulation in patients with different degrees of chronic heart failure. We 
      studied 30 patients with stable chronic heart failure and 15 controls of similar 
      age. ECG, arterial blood pressure and respiratory signal were recorded at rest, 
      during controlled respiration and during passive head-up tilting. R-R interval 
      periods of 256-512 were analysed. Routine 2D echocardiogram and Doppler studies 
      were also carried out. As expected, we found a decrease in the mean and variance 
      of R-R intervals in patients with sever heart failure. In New York Heart 
      Association (NYHA) class II patients, the power spectral pattern of R-R 
      variability was characterized by the predominance of the low frequency component 
      (72 +/- 3 nu), considered a marker of sympathetic activity, and by its 
      unresponsiveness to tilting. Patients in NYHA class III also presented blunted 
      changes in spectral components during tilting. A drastic decrease in the variance 
      of R-R intervals (191 +/- 58 vs 1056 +/- 149 ms2 in controls) and an almost 
      complete absence of the low frequency spectral component (8 +/- 3 nu) were 
      present in patients in NYHA class IV. Controlled respiration, which in normal 
      subjects decreased the low frequency component, induced changes that blunted 
      progressively as heart failure increased. These data suggest that autonomic 
      neural modulation and cardiovascular response to neural activity differ at 
      different stages of the disease.
FAU - Guzzetti, S
AU  - Guzzetti S
AD  - Centro Ricerche Cardiovascolari del CNR, Milano, Italy.
FAU - Cogliati, C
AU  - Cogliati C
FAU - Turiel, M
AU  - Turiel M
FAU - Crema, C
AU  - Crema C
FAU - Lombardi, F
AU  - Lombardi F
FAU - Malliani, A
AU  - Malliani A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Analysis of Variance
MH  - Autonomic Nervous System/*physiopathology
MH  - Blood Pressure
MH  - Chronic Disease
MH  - Disease Progression
MH  - Echocardiography, Doppler
MH  - Electrocardiography
MH  - Heart Failure/diagnostic imaging/*physiopathology
MH  - Heart Rate
MH  - Humans
MH  - Middle Aged
MH  - Plethysmography
MH  - Posture/*physiology
MH  - Respiration/*physiology
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.eurheartj.a061053 [doi]
PST - ppublish
SO  - Eur Heart J. 1995 Aug;16(8):1100-7. doi: 
      10.1093/oxfordjournals.eurheartj.a061053.