PMID- 8666027
OWN - NLM
STAT- MEDLINE
DCOM- 19960807
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 287
IP  - 1
DP  - 1995 Dec 4
TI  - Brain enzyme activities after intracerebroventricular injection of streptozotocin 
      in rats receiving acetyl-L-carnitine.
PG  - 65-71
AB  - Intracerebroventricular (i.c.v.) injection of streptozotocin has been introduced 
      as a means to inhibit glucose utilization in the rat brain, and to induce changes 
      in neurotransmitter systems and behavior which resemble those seen in Alzheimer's 
      disease. In this study, enzyme activities previously investigated in Alzheimer's 
      disease (peptidases, dehydrogenases and acetyltransferases) were measured in the 
      septum and hippocampus of control and streptozotocin-treated rats. 
      Streptozotocin-treated rats receiving acetyl-L-carnitine were also included in 
      the experiments, to assess possible neuroprotective effects of this substance. 
      All enzyme activities in the septum were affected by streptozotocin, with the 
      exception of choline acetyltransferase activity. By contrast, choline 
      acetyltransferase activity was the only enzyme activity affected in the 
      hippocampus. The weight of the septum was reduced in streptozotocin-treated 
      animals. These findings indicate that i.c.v. injection of streptozotocin causes 
      septal damage and enzymatic changes that do not closely resemble those seen in 
      Alzheimer's disease, which are more specific. Acetyl-L-carnitine partly prevented 
      this damage, as reflected by an attenuation of the streptozotocin-induced 
      decrease in hippocampal choline acetyltransferase activity. This finding 
      indicates that streptozotocin-treated rats may be valuable to test possible 
      neuroprotective effects of drugs.
FAU - Terwel, D
AU  - Terwel D
AD  - Department of Psychiatry and Neuropsychology, University of Limburg, Maastricht, 
      Netherlands.
FAU - Prickaerts, J
AU  - Prickaerts J
FAU - Meng, F
AU  - Meng F
FAU - Jolles, J
AU  - Jolles J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Nootropic Agents)
RN  - 5W494URQ81 (Streptozocin)
RN  - 6DH1W9VH8Q (Acetylcarnitine)
SB  - IM
MH  - Acetylcarnitine/*administration & dosage
MH  - Alzheimer Disease/enzymology
MH  - Animals
MH  - Anti-Bacterial Agents/administration & dosage/*pharmacology
MH  - Brain/*enzymology
MH  - Hippocampus/enzymology
MH  - Injections, Intraventricular
MH  - Male
MH  - Neuroprotective Agents/*administration & dosage
MH  - Nootropic Agents/*administration & dosage
MH  - Rats
MH  - Streptozocin/administration & dosage/*pharmacology
EDAT- 1995/12/04 00:00
MHDA- 1995/12/04 00:01
CRDT- 1995/12/04 00:00
PHST- 1995/12/04 00:00 [pubmed]
PHST- 1995/12/04 00:01 [medline]
PHST- 1995/12/04 00:00 [entrez]
AID - 0014-2999(95)00475-4 [pii]
AID - 10.1016/0014-2999(95)00475-4 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1995 Dec 4;287(1):65-71. doi: 10.1016/0014-2999(95)00475-4.