PMID- 8666104
OWN - NLM
STAT- MEDLINE
DCOM- 19960805
LR  - 20190821
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 8
IP  - 12
DP  - 1995 Dec
TI  - Outcome of wheeze in childhood: the influence of atopy.
PG  - 2081-7
AB  - We have previously demonstrated that the adult outcome of childhood asthma 
      differs from that of wheeze occurring only in the presence of infection. This 
      paper examines the role of atopy in relation to outcome. We investigated the 
      atopic status, current symptoms and bronchial reactivity to methacholine of 235 
      subjects aged 34-40 yrs, originally classified at age 10-15 yrs as having asthma 
      (asthma group), wheeze only in the presence of infection (wheezy group), or no 
      respiratory symptoms (comparison group). Subjects from the original asthma group 
      were more likely to be atopic as defined by skin test reactivity, total serum 
      immunoglobulin E (IgE) measurement or specific IgE radio allergosorbent test 
      (RAST) measurement than those from the wheezy group. The wheezy group differed 
      significantly from the reference group only in RAST results, when other variables 
      were taken into account. In a logistic regression model, the important 
      independent predictors for adult wheezing symptoms were original group, atopy and 
      current smoking. Methacholine responsiveness was independently associated with 
      original group (the asthma group were more likely to respond positively), atopy 
      and female gender. The results suggest that atopy is an important predictor for 
      wheeze and bronchial hyperreactivity in middle age. However, the difference in 
      outcome for children who had asthma compared to those who had wheeze only in the 
      presence of infection cannot be explained by atopy alone.
FAU - Ross, S
AU  - Ross S
AD  - Dept of Medicine and Therapeutics, and Sociology, University of Aberdeen, 
      Scotland.
FAU - Godden, D J
AU  - Godden DJ
FAU - Abdalla, M
AU  - Abdalla M
FAU - McMurray, D
AU  - McMurray D
FAU - Douglas, A
AU  - Douglas A
FAU - Oldman, D
AU  - Oldman D
FAU - Friend, J A
AU  - Friend JA
FAU - Legge, J S
AU  - Legge JS
FAU - Douglas, J G
AU  - Douglas JG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asthma/*diagnosis
MH  - Bronchial Provocation Tests
MH  - Child
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*diagnosis
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Radioallergosorbent Test
MH  - Respiratory Sounds/*diagnosis
MH  - Sex Factors
MH  - Skin Tests
MH  - Smoking
MH  - Time Factors
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1183/09031936.95.0812081 [doi]
PST - ppublish
SO  - Eur Respir J. 1995 Dec;8(12):2081-7. doi: 10.1183/09031936.95.0812081.