PMID- 8668340
OWN - NLM
STAT- MEDLINE
DCOM- 19960808
LR  - 20071114
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 12
IP  - 10
DP  - 1996 May 16
TI  - Loss of heterozygosity of chromosome 17 in human borderline and invasive 
      epithelial ovarian tumors.
PG  - 2147-53
AB  - Polymerase chain reaction (PCR) analysis of microsatellite polymorphisms 
      corresponding to four loci which map to chromosome 17p and 11 loci which map to 
      chromosome 17q was performed to screen for loss of heterozygosity (LOH) in paired 
      normal and tumor tissues from 27 cases of borderline epithelial ovarian tumors 
      (BEOT) and 32 cases of invasive epithelial ovarian cancers (IOC). LOH was 
      observed in six of 27 (22%) of the borderline tumors and in 29 of 32 (90%) of the 
      invasive ovarian cancers (P<0.001). At all 15 loci studied, a lower percentage of 
      allelic loss was detected in borderline tumors (0-14%) vs invasive cancer 
      (8-93%). At eight loci this difference was statistically significant. For IOC, 
      one common loss region was identified on chromosome 17p and four distinct common 
      loss regions were on chromosome 17q, which supports the notion that multiple 
      tumor suppressors may reside on chromosome 17 in IOC. These data suggest that LOH 
      on chromosome 17 is an infrequent event in BEOT compared with IOC and therefore 
      may not be important in the distinct pathogenesis of BEOT.
FAU - Wertheim, I
AU  - Wertheim I
AD  - Department of Obsterics, Gynecology and Reproductive Biology, Brigham and Women's 
      Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
FAU - Tangir, J
AU  - Tangir J
FAU - Muto, M G
AU  - Muto MG
FAU - Welch, W R
AU  - Welch WR
FAU - Berkowitz, R S
AU  - Berkowitz RS
FAU - Chen, W Y
AU  - Chen WY
FAU - Mok, S C
AU  - Mok SC
LA  - eng
GR  - R01 CA63381/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
SB  - IM
MH  - Alleles
MH  - *Chromosomes, Human, Pair 17
MH  - Disease Progression
MH  - Epithelium/pathology
MH  - Female
MH  - *Gene Deletion
MH  - Heterozygote
MH  - Humans
MH  - Neoplasm Invasiveness
MH  - Ovarian Neoplasms/*genetics/*pathology
MH  - Polymerase Chain Reaction
EDAT- 1996/05/16 00:00
MHDA- 1996/05/16 00:01
CRDT- 1996/05/16 00:00
PHST- 1996/05/16 00:00 [pubmed]
PHST- 1996/05/16 00:01 [medline]
PHST- 1996/05/16 00:00 [entrez]
PST - ppublish
SO  - Oncogene. 1996 May 16;12(10):2147-53.