PMID- 8669432
OWN - NLM
STAT- MEDLINE
DCOM- 19960808
LR  - 20190815
IS  - 0272-6386 (Print)
IS  - 0272-6386 (Linking)
VI  - 28
IP  - 1 Suppl 1
DP  - 1996 Jul
TI  - Nonrenal toxicities of acetaminophen, aspirin, and nonsteroidal anti-inflammatory 
      agents.
PG  - S63-70
AB  - Approximately 2% of the United States population consumes an analgesic, 
      antipyretic, or nonsteroidal antiinflammatory drug (NSAID) each day. Aspirin and 
      acetaminophen have been available to the public without a prescription 
      (over-the-counter) for decades, while most NSAIDs are still only available with a 
      prescription from a physician. The recent trend of switching NSAIDs from 
      prescription to over-the-counter status may be perceived by some as an indication 
      of their inherent safety. However, all these agents have been associated with a 
      unique but overlapping safety profile. In fact, significant adverse events (AEs) 
      on multiple organ systems, including the kidney and gastrointestinal tract, have 
      been reported with most of these agents. In this review, the incidence of the 
      nonrenal AEs of aspirin, acetaminophen, and selected NSAIDs are tabulated. The 
      strengths of the causative associations are highlighted, the relative risks for 
      the gastrointestinal and cardiovascular AEs are discussed, and the relationship 
      to patient risk factors and drug characteristics, such as dose and half-life, are 
      reviewed. The selection of the optimal agent for an individual patient depends on 
      the balance between the desired pharmacodynamic response, the patient's 
      pharmacotherapy history, and the degree of AE risk one is willing to accept. 
      Therapy should be initiated in all settings with the lowest possible dosage since 
      the incidence of the major AEs is dose related.
FAU - Matzke, G R
AU  - Matzke GR
AD  - Department of Pharmacy and Therapeutics, School of Pharmacy, University of 
      Pittsburgh, PA 15261, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney 
      Foundation
JID - 8110075
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Nonprescription Drugs)
RN  - 362O9ITL9D (Acetaminophen)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Acetaminophen/*adverse effects/toxicity
MH  - Analgesics, Non-Narcotic/*adverse effects/toxicity
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects/toxicity
MH  - Aspirin/*adverse effects/toxicity
MH  - Humans
MH  - Nonprescription Drugs/adverse effects/toxicity
RF  - 38
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - S0272-6386(96)90571-5 [pii]
AID - 10.1016/s0272-6386(96)90571-5 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 1996 Jul;28(1 Suppl 1):S63-70. doi: 
      10.1016/s0272-6386(96)90571-5.