PMID- 8671332
OWN - NLM
STAT- MEDLINE
DCOM- 19961121
LR  - 20190512
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 11
IP  - 4
DP  - 1996 Apr
TI  - Transvaginal interstitial laser treatment of the ovary: a feasibility study in 
      cows.
PG  - 808-13
AB  - In 12 cows, transvaginal interstitial laser treatment (TILT) of the ovaries was 
      performed using a neodynium:yttrium aluminium-garnet laser to investigate the 
      feasibility of a new treatment approach for clomiphene-resistant patients with 
      chronic hyperandrogenic anovulation. Powers of 1 and 2 W during 5 min of exposure 
      were used. Sonographic changes of thermal damage during TILT, the extent and 
      healing of the lesions by light microscopy and ultrasound during 3 month 
      follow-up and adhesion formation were studied. During laser irradiation, a 
      hyperechogenic zone developed around the fibre tip, with a mean +/- SD diameter 
      of 4.4 +/- 2.0 mm at 1 W and 6.9 +/- 1.5 mm at 2. W. The mean diameters of the 
      histological lesions 2 days after treatment were 7.3 +/- 2.5 mm at 1 W and 13.0 
      +/- 2.1 mm at 2 W. During follow-up, the mean diameter of both the histologically 
      and the sonographically assessed lesions decreased, although transvaginal 
      sonography (TVS) systematically and significantly underestimated the thermal 
      damage. Lesions healed by fibrosis and no adhesions were present. TILT of the 
      ovaries in cows is easy to perform and produces central or subcapsular necrosis 
      without adhesions. TVS gives an indication of thermal damage but underestimates 
      the extent of tissue damage in cow ovaries. Obviously, this study does not allow 
      conclusions to be drawn concerning its safety and efficacy in man.
FAU - Kaaijk, E M
AU  - Kaaijk EM
AD  - Laser Centre, Division of Gynaecology, Amsterdam, The Netherlands.
FAU - Pieterse, M C
AU  - Pieterse MC
FAU - Beek, J F
AU  - Beek JF
FAU - van der Veen, F
AU  - van der Veen F
FAU - ten Kate, F J
AU  - ten Kate FJ
FAU - Lammes, F B
AU  - Lammes FB
FAU - van Gemert, M J
AU  - van Gemert MJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Animals
MH  - Anovulation/*surgery
MH  - Cattle
MH  - Female
MH  - Follow-Up Studies
MH  - Laser Therapy/*methods
MH  - Ovary/diagnostic imaging/injuries/*surgery
MH  - Ultrasonography
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.humrep.a019258 [doi]
PST - ppublish
SO  - Hum Reprod. 1996 Apr;11(4):808-13. doi: 10.1093/oxfordjournals.humrep.a019258.